Emergence of collective territorial defense in bacterial communities: Horizontal gene transfer can stabilize microbiomes

János Juhász, Attila Kertész-Farkas, Dóra Szabó, Sándor Pongor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Multispecies bacterial communities such as the microbiota of the gastrointestinal tract can be remarkably stable and resilient even though they consist of cells and species that compete for resources and also produce a large number of antimicrobial agents. Computational modeling suggests that horizontal transfer of resistance genes may greatly contribute to the formation of stable and diverse communities capable of protecting themselves with a battery of antimicrobial agents while preserving a varied metabolic repertoire of the constituent species. In other words horizontal transfer of resistance genes makes a community compatible in terms of exoproducts and capable to maintain a varied and mature metagenome. The same property may allow microbiota to protect a host organism, or if used as a microbial therapy, to purge pathogens and restore a protective environment.

Original languageEnglish
Article numbere95511
JournalPloS one
Volume9
Issue number4
DOIs
Publication statusPublished - Apr 22 2014

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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