Emergence and characterisation of pandemic H1N1 influenza viruses in Hungarian swine herds

Ádám Bálint, István Kiss, Krisztián Bányai, Imre Biksi, Katalin Szentpáli-Gavallér, Tibor Magyar, István Jankovics, Mónika Rózsa, Bálint Szalai, Mária Takács, Ádám Tóth, Ádám Dán

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In 2010, two novel porcine H1N1 influenza viruses were isolated from pigs with influenza-like illness in Hungarian swine herds. Sequence and phylogenetic analysis of these strains revealed that they shared molecular features with the pandemic H1N1 influenza virus strains, which emerged globally during 2009. The PB2, HA and NA genes contained unique amino acid changes compared to the available new H1N1 influenza virus sequences of pig origin. Furthermore, the investigated strains could be separated with respect to parallel amino acid substitutions affecting the polymerase genes (PB2, PB1 and PA) and the nucleoprotein (NP) gene, supporting the proposed complementarities between these proteins, all required for the viral fitness. Molecular characterisation of two Hungarian human pandemic H1N1 isolates was also performed, so that we could compare contemporaneous strains of different host species origins. Shared molecular motifs in various genes of animal and human influenza strains suggested that the Hungarian porcine strains could have originated from humans through direct interspecies transmission. This study is among the few that support the natural human-to-pig transmission of the pandemic H1N1 influenza virus.

Original languageEnglish
Pages (from-to)125-134
Number of pages10
JournalActa veterinaria Hungarica
Volume61
Issue number1
DOIs
Publication statusPublished - Mar 1 2013

Keywords

  • Human
  • Hungary
  • Interspecies transmission
  • Porcine
  • Reverse zoonosis

ASJC Scopus subject areas

  • veterinary(all)

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    Bálint, Á., Kiss, I., Bányai, K., Biksi, I., Szentpáli-Gavallér, K., Magyar, T., Jankovics, I., Rózsa, M., Szalai, B., Takács, M., Tóth, Á., & Dán, Á. (2013). Emergence and characterisation of pandemic H1N1 influenza viruses in Hungarian swine herds. Acta veterinaria Hungarica, 61(1), 125-134. https://doi.org/10.1556/AVet.2012.059