Elevation of met5-enkephalin and β-endorphin hypothalamic content in rats receiving anorectic drugs: Differences between d-fenfluramine and d-amphetamine

L. G. Harsing, H. Y.T. Yang, S. Govoni, E. Costa

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

D-Fenfluramine, an anorectic that releases serotonin (5-HT), repeatedly injected in rats (15 mg/kg per day) enhanced the met5-enkephalin and β-endorphin content of the hypothalamus. The onset of this effect was slow, reaching a peak at 5 days; the increase in β-endorphin gradually declined toward control level while the drug was still being administered although that of met-enkephalin persisted for 15 days. The elevation of the opioid peptide content of the hypothalamus was temporally associated with a slowing in the rate of body weight increase. A transient, small, increase in striatal met-enkephalin content was also induced by repeated D-fenfluramine injections: however the metenkephalin content of frontal cortex, hippocampus and brainstem was not affected. A modification of the β-endorphin content of hypothalamus was not seen after acute injection of D-fenfluramine or D-amphetamine but an increase was observed during repeated treatment with D-fenfluramine. Repeated injections of D-amphetamine for 5 days (4.5 mg/kg per day) failed to increase either the met-enkephalin or the β-endophin content of the hypothalamus. These data suggest that the anorexia elicited by repeated injections of D-fenfluramine but not that elicited by D-amphetamine, includes a participation by hypothalamic and β-endosphin stores.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalNeuropharmacology
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 1982

Keywords

  • anorectic drugs
  • hypothalamus
  • met-enkephalin
  • β-endorphin

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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