Elevation of intracellular calcium content in area CA1 of hippocampus is not directly correlated with the development of long-term potentiation

L. Siklós, U. Kuhnt, A. Mihály, F. Joó

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Electron microscopic localization of calcium-containing mitochondria in stratum radiatum of CA1 of hippocampal slices was performed after (I) low-frequency stimulation, (2) high-frequency stimulation, and (3) blocking N-methyl-d-aspartate (NMDA) receptors during high-frequency stimulation. Dendritic mitochondria containing Ca deposits were found in a narrow band of stratum radiatum 280-350 μm distant from stratum pyramidale. Axonal mitochondria containing Ca deposits were evently distributed in stratum radiatum. The total number of calcium containing-mitochondria was highest in long-term potentiated slices, and less in slices treated with APV; the lowest values were obtained with low-frequency stimulation.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalNeuroscience Letters
Volume107
Issue number1-3
DOIs
Publication statusPublished - Dec 15 1989

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Long-Term Potentiation
Hippocampus
Mitochondria
Calcium
Hippocampal CA1 Region
Electrons

Keywords

  • Calcium
  • d-2-Amino-5-phosphonovalerate
  • Guinea pig
  • Hippocampus
  • In vitro
  • Long-term potentiation
  • Mitochondrium

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "Electron microscopic localization of calcium-containing mitochondria in stratum radiatum of CA1 of hippocampal slices was performed after (I) low-frequency stimulation, (2) high-frequency stimulation, and (3) blocking N-methyl-d-aspartate (NMDA) receptors during high-frequency stimulation. Dendritic mitochondria containing Ca deposits were found in a narrow band of stratum radiatum 280-350 μm distant from stratum pyramidale. Axonal mitochondria containing Ca deposits were evently distributed in stratum radiatum. The total number of calcium containing-mitochondria was highest in long-term potentiated slices, and less in slices treated with APV; the lowest values were obtained with low-frequency stimulation.",
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T1 - Elevation of intracellular calcium content in area CA1 of hippocampus is not directly correlated with the development of long-term potentiation

AU - Siklós, L.

AU - Kuhnt, U.

AU - Mihály, A.

AU - Joó, F.

PY - 1989/12/15

Y1 - 1989/12/15

N2 - Electron microscopic localization of calcium-containing mitochondria in stratum radiatum of CA1 of hippocampal slices was performed after (I) low-frequency stimulation, (2) high-frequency stimulation, and (3) blocking N-methyl-d-aspartate (NMDA) receptors during high-frequency stimulation. Dendritic mitochondria containing Ca deposits were found in a narrow band of stratum radiatum 280-350 μm distant from stratum pyramidale. Axonal mitochondria containing Ca deposits were evently distributed in stratum radiatum. The total number of calcium containing-mitochondria was highest in long-term potentiated slices, and less in slices treated with APV; the lowest values were obtained with low-frequency stimulation.

AB - Electron microscopic localization of calcium-containing mitochondria in stratum radiatum of CA1 of hippocampal slices was performed after (I) low-frequency stimulation, (2) high-frequency stimulation, and (3) blocking N-methyl-d-aspartate (NMDA) receptors during high-frequency stimulation. Dendritic mitochondria containing Ca deposits were found in a narrow band of stratum radiatum 280-350 μm distant from stratum pyramidale. Axonal mitochondria containing Ca deposits were evently distributed in stratum radiatum. The total number of calcium containing-mitochondria was highest in long-term potentiated slices, and less in slices treated with APV; the lowest values were obtained with low-frequency stimulation.

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KW - In vitro

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