Elevated white blood cell count, CRP and fibrinogen levels are not associated with increased anti-endothelial and anti-ox-LDL antibody, MCP-1, and RANTES levels in early onset occlusive carotid artery disease

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Abstract

Background. Inflammatory processes have importance in atherosclerosis. We evaluated if subjects below 55 years of age with occlusive carotid artery disease have higher serum levels of antibodies against oxidized LDL and endothelial cells and the chemokines MCP-1 and RANTES than age matched subjects without atherosclerosis. Methods and results. Sixty patients with occlusive carotid artery disease (stenosis or occlusion) and 30 age-matched controls participated in the study. We measured the degree of carotid artery stenosis and intima-media thickness (IMT) by duplex ultrasound. White blood cell count (WBC), C-reactive protein (CRP), and fibrinogen levels were significantly higher in patients (means ± SD: 7.5 ± 1.8 vs. 6.1 ± 1.1 G/L, p <0.001; 7.7 ± 20.7 vs. 2.5 ± 1.9 mg/L, p = 0.015; and 3.7 ± 0.9 vs. 3.1 ± 0.5 g/L, p <0.001, respectively). Antibody levels against oxidized LDL and endothelial cells (21.1 ± 22.9 and 19.9 ± 15.3 EU/mL, p = 0.6; and 19 ± 15 vs. 20 ± 9 U/mL, p = 0.07) and RANTES and MCP-1 levels (72.4 ± 32.3 vs. 73.8 ± 27.3 ng/mL, p = 0.7; and 468 ± 1041 vs. 318 ± 131 pg/mL, p = 0.7) did not differ significantly between patients and controls and did not correlate with IMT. Conclusions. Higher levels of WBC, CRP, and fibrinogen suggest an ongoing inflammation in early-onset carotid atherosclerosis, but increased IMT is not associated by the elevation of serum levels of chemokines and antibodies evaluated in this study.

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalCytokine
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 2007

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Chemokine CCL5
Carotid Artery Diseases
Leukocyte Count
C-Reactive Protein
Fibrinogen
Blood
Carotid Stenosis
Endothelial cells
Cells
Chemokines
Antibodies
Atherosclerosis
Endothelial Cells
Serum
Ultrasonics
Inflammation
oxidized low density lipoprotein

Keywords

  • Atherosclerosis
  • Cytokines
  • Inflammation
  • MCP-1
  • RANTES

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

Cite this

@article{2cd9a23a06da442aaca6c99ed07ecc4c,
title = "Elevated white blood cell count, CRP and fibrinogen levels are not associated with increased anti-endothelial and anti-ox-LDL antibody, MCP-1, and RANTES levels in early onset occlusive carotid artery disease",
abstract = "Background. Inflammatory processes have importance in atherosclerosis. We evaluated if subjects below 55 years of age with occlusive carotid artery disease have higher serum levels of antibodies against oxidized LDL and endothelial cells and the chemokines MCP-1 and RANTES than age matched subjects without atherosclerosis. Methods and results. Sixty patients with occlusive carotid artery disease (stenosis or occlusion) and 30 age-matched controls participated in the study. We measured the degree of carotid artery stenosis and intima-media thickness (IMT) by duplex ultrasound. White blood cell count (WBC), C-reactive protein (CRP), and fibrinogen levels were significantly higher in patients (means ± SD: 7.5 ± 1.8 vs. 6.1 ± 1.1 G/L, p <0.001; 7.7 ± 20.7 vs. 2.5 ± 1.9 mg/L, p = 0.015; and 3.7 ± 0.9 vs. 3.1 ± 0.5 g/L, p <0.001, respectively). Antibody levels against oxidized LDL and endothelial cells (21.1 ± 22.9 and 19.9 ± 15.3 EU/mL, p = 0.6; and 19 ± 15 vs. 20 ± 9 U/mL, p = 0.07) and RANTES and MCP-1 levels (72.4 ± 32.3 vs. 73.8 ± 27.3 ng/mL, p = 0.7; and 468 ± 1041 vs. 318 ± 131 pg/mL, p = 0.7) did not differ significantly between patients and controls and did not correlate with IMT. Conclusions. Higher levels of WBC, CRP, and fibrinogen suggest an ongoing inflammation in early-onset carotid atherosclerosis, but increased IMT is not associated by the elevation of serum levels of chemokines and antibodies evaluated in this study.",
keywords = "Atherosclerosis, Cytokines, Inflammation, MCP-1, RANTES",
author = "M. Magyar and D. Bereczki and I. Cs{\'i}pő and E. Gyimesi and L. Csiba and A. Valikovics and J. Balla and S. Sipka",
year = "2007",
month = "1",
doi = "10.1016/j.cyto.2007.02.014",
language = "English",
volume = "37",
pages = "44--50",
journal = "Cytokine",
issn = "1043-4666",
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T1 - Elevated white blood cell count, CRP and fibrinogen levels are not associated with increased anti-endothelial and anti-ox-LDL antibody, MCP-1, and RANTES levels in early onset occlusive carotid artery disease

AU - Magyar, M.

AU - Bereczki, D.

AU - Csípő, I.

AU - Gyimesi, E.

AU - Csiba, L.

AU - Valikovics, A.

AU - Balla, J.

AU - Sipka, S.

PY - 2007/1

Y1 - 2007/1

N2 - Background. Inflammatory processes have importance in atherosclerosis. We evaluated if subjects below 55 years of age with occlusive carotid artery disease have higher serum levels of antibodies against oxidized LDL and endothelial cells and the chemokines MCP-1 and RANTES than age matched subjects without atherosclerosis. Methods and results. Sixty patients with occlusive carotid artery disease (stenosis or occlusion) and 30 age-matched controls participated in the study. We measured the degree of carotid artery stenosis and intima-media thickness (IMT) by duplex ultrasound. White blood cell count (WBC), C-reactive protein (CRP), and fibrinogen levels were significantly higher in patients (means ± SD: 7.5 ± 1.8 vs. 6.1 ± 1.1 G/L, p <0.001; 7.7 ± 20.7 vs. 2.5 ± 1.9 mg/L, p = 0.015; and 3.7 ± 0.9 vs. 3.1 ± 0.5 g/L, p <0.001, respectively). Antibody levels against oxidized LDL and endothelial cells (21.1 ± 22.9 and 19.9 ± 15.3 EU/mL, p = 0.6; and 19 ± 15 vs. 20 ± 9 U/mL, p = 0.07) and RANTES and MCP-1 levels (72.4 ± 32.3 vs. 73.8 ± 27.3 ng/mL, p = 0.7; and 468 ± 1041 vs. 318 ± 131 pg/mL, p = 0.7) did not differ significantly between patients and controls and did not correlate with IMT. Conclusions. Higher levels of WBC, CRP, and fibrinogen suggest an ongoing inflammation in early-onset carotid atherosclerosis, but increased IMT is not associated by the elevation of serum levels of chemokines and antibodies evaluated in this study.

AB - Background. Inflammatory processes have importance in atherosclerosis. We evaluated if subjects below 55 years of age with occlusive carotid artery disease have higher serum levels of antibodies against oxidized LDL and endothelial cells and the chemokines MCP-1 and RANTES than age matched subjects without atherosclerosis. Methods and results. Sixty patients with occlusive carotid artery disease (stenosis or occlusion) and 30 age-matched controls participated in the study. We measured the degree of carotid artery stenosis and intima-media thickness (IMT) by duplex ultrasound. White blood cell count (WBC), C-reactive protein (CRP), and fibrinogen levels were significantly higher in patients (means ± SD: 7.5 ± 1.8 vs. 6.1 ± 1.1 G/L, p <0.001; 7.7 ± 20.7 vs. 2.5 ± 1.9 mg/L, p = 0.015; and 3.7 ± 0.9 vs. 3.1 ± 0.5 g/L, p <0.001, respectively). Antibody levels against oxidized LDL and endothelial cells (21.1 ± 22.9 and 19.9 ± 15.3 EU/mL, p = 0.6; and 19 ± 15 vs. 20 ± 9 U/mL, p = 0.07) and RANTES and MCP-1 levels (72.4 ± 32.3 vs. 73.8 ± 27.3 ng/mL, p = 0.7; and 468 ± 1041 vs. 318 ± 131 pg/mL, p = 0.7) did not differ significantly between patients and controls and did not correlate with IMT. Conclusions. Higher levels of WBC, CRP, and fibrinogen suggest an ongoing inflammation in early-onset carotid atherosclerosis, but increased IMT is not associated by the elevation of serum levels of chemokines and antibodies evaluated in this study.

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KW - Inflammation

KW - MCP-1

KW - RANTES

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