Elevated tumor necrosis factor-alpha expression in periapical lesions infected by epstein-barr virus

Katinka Hernádi, Eszter Gyöngyösi, Beáta Mészáros, Levente Szakács, Anita Szalmás, Eszter Csoma, Richárd Mogyorósi, Levente Czompa, G. Veress, István Varga, I. Márton, József Kónya

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Introduction: In apical periodontitis, there is an intense inflammatory response to endodontopathogenic bacteria, an essential component of the pathogenic microbiota. The inflammation can be aggravated by herpesviruses acting as nonessential pathogens in periapical lesions. This study aimed to determine the levels of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) in periapical lesions in relation to local occurrence of Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6), and human herpesvirus 8 (HHV-8). Methods: Fifty-eight samples with apical periodontitis and 20 clinically healthy gingival control tissues were collected. Viral DNA was determined with nested polymerase chain reaction, and cytokine mRNA expression was detected with real-time polymerase chain reaction assays. Results: Periapical lesions harbored EBV (75.9%) and HHV-6 (22.4%) at significantly higher frequencies compared with controls (P

Original languageEnglish
Pages (from-to)456-460
Number of pages5
JournalJournal of Endodontics
Volume39
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Periapical Periodontitis
Human Herpesvirus 6
Human Herpesvirus 4
Tumor Necrosis Factor-alpha
Human Herpesvirus 8
Herpesviridae
Microbiota
Viral DNA
Cytomegalovirus
Transforming Growth Factor beta
Real-Time Polymerase Chain Reaction
Cytokines
Inflammation
Bacteria
Polymerase Chain Reaction
Messenger RNA

Keywords

  • Epstein-Barr virus
  • human cytomegalovirus
  • human herpesvirus 6
  • periapical lesion
  • real time PCR
  • TGF-beta
  • TNF-alpha

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Hernádi, K., Gyöngyösi, E., Mészáros, B., Szakács, L., Szalmás, A., Csoma, E., ... Kónya, J. (2013). Elevated tumor necrosis factor-alpha expression in periapical lesions infected by epstein-barr virus. Journal of Endodontics, 39(4), 456-460. https://doi.org/10.1016/j.joen.2012.12.028

Elevated tumor necrosis factor-alpha expression in periapical lesions infected by epstein-barr virus. / Hernádi, Katinka; Gyöngyösi, Eszter; Mészáros, Beáta; Szakács, Levente; Szalmás, Anita; Csoma, Eszter; Mogyorósi, Richárd; Czompa, Levente; Veress, G.; Varga, István; Márton, I.; Kónya, József.

In: Journal of Endodontics, Vol. 39, No. 4, 04.2013, p. 456-460.

Research output: Contribution to journalArticle

Hernádi, K, Gyöngyösi, E, Mészáros, B, Szakács, L, Szalmás, A, Csoma, E, Mogyorósi, R, Czompa, L, Veress, G, Varga, I, Márton, I & Kónya, J 2013, 'Elevated tumor necrosis factor-alpha expression in periapical lesions infected by epstein-barr virus', Journal of Endodontics, vol. 39, no. 4, pp. 456-460. https://doi.org/10.1016/j.joen.2012.12.028
Hernádi, Katinka ; Gyöngyösi, Eszter ; Mészáros, Beáta ; Szakács, Levente ; Szalmás, Anita ; Csoma, Eszter ; Mogyorósi, Richárd ; Czompa, Levente ; Veress, G. ; Varga, István ; Márton, I. ; Kónya, József. / Elevated tumor necrosis factor-alpha expression in periapical lesions infected by epstein-barr virus. In: Journal of Endodontics. 2013 ; Vol. 39, No. 4. pp. 456-460.
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