Elevated serum tumor necrosis factor-alpha concentrations and bioactivity in Type 2 diabetics and patients with android type obesity

G. Winkler, F. Salamon, G. Harmos, D. Salamon, G. Speer, O. Szekeres, P. Hajós, M. Kovács, K. Simon, K. Cseh

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The role of tumor necrosis factor-alpha in insulin resistance has been studied in 59 patients with Type 2 diabetes, 28 with android type obesity and 35 healthy lean controls. Immunoreactive concentrations and bioactivity of serum tumor necrosis factor-alpha have repeatedly been determined in 8 weeks intervals for 12 months, five times per patients, by using ELISA and L929 cell cytotoxicity bioassay. Significantly higher immunoreactive tumor necrosis factor-alpha concentrations and bioactivity have been found in both, the Type 2 diabetic and obese groups as compared to the healthy persons. Tumor necrosis factor-alpha concentrations and bioactivity have showed a significant positive linear correlation with the elevated basal serum C- peptide levels and body mass indexes in both groups of patients. According to these data the cytokine might play a role in insulin resistance in obesity as well in Type 2 diabetes.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume42
Issue number3
DOIs
Publication statusPublished - Dec 1 1998

Keywords

  • C-peptide
  • Insulin resistance
  • Obesity
  • Tumor necrosis factor-alpha
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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