Emelkedett szérum-dipeptidil-peptidáz-4 enzimaktivitá sa 1-es típusú diabetesben

összehasonlíto″ vizsgálat

Translated title of the contribution: Elevated serum dipeptidyl peptidase-4 activity in type 1 diabetes mellitus: A direct comparison

Tímea Varga, G. Firneisz, Géza Nagy, A. Somogyi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Dipeptidyl peptidase-4 (DPP-4) has an important role in the carbohydrate metabolism with the degradation of incretin hormones. Aim: We assessed the serum DPP-4 activity both in fasting and postprandial condition in patients with type 1-, type 2 diabetes and healthy controls. Methods: Serum DPP-4 activities were determined at fasting sate and at 60 and 180 minutes after test meal. DPP-4 activity was measured by microplate-based kinetic assay in 41 type 1-, and in 87 type 2 diabetic patients and in 25 healthy volunteers. Results: Serum DPP-4 activities were found significantly higher both in fasting and postprandial state in patients with type 1 diabetes than in type 2 and control subjects. No change in the enzyme activities was found after test meal. Correlation was neither detected between the fasting plasma glucose nor between the HbA 1C and the DPP-4 values in any of the groups studied. Conclusions: Results suggest that it is not the hyperglycemia, rather the type of diabetes which determinates the serum DPP-4 enzymatic activity. The exact background of this phenomenon is not yet clear, however, increased serum DPP-4 enzyme activity in type 1 diabetes mellitus may refer to pancreatic autoimmune process, concomitant autoimmune diseases, hormonal feed back mechanism, or even target organ damage.

Original languageHungarian
Pages (from-to)899-902
Number of pages4
JournalOrvosi Hetilap
Volume151
Issue number22
DOIs
Publication statusPublished - May 1 2010

Fingerprint

Dipeptidyl Peptidase 4
Type 1 Diabetes Mellitus
Serum
Fasting
Meals
Incretins
Carbohydrate Metabolism
Enzymes
Hyperglycemia
Type 2 Diabetes Mellitus
Autoimmune Diseases
Healthy Volunteers
Hormones
Glucose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Emelkedett szérum-dipeptidil-peptidáz-4 enzimaktivitá sa 1-es típusú diabetesben : összehasonlíto″ vizsgálat. / Varga, Tímea; Firneisz, G.; Nagy, Géza; Somogyi, A.

In: Orvosi Hetilap, Vol. 151, No. 22, 01.05.2010, p. 899-902.

Research output: Contribution to journalArticle

@article{750bfb97872b40389da43f95d4242ca4,
title = "Emelkedett sz{\'e}rum-dipeptidil-peptid{\'a}z-4 enzimaktivit{\'a} sa 1-es t{\'i}pus{\'u} diabetesben: {\"o}sszehasonl{\'i}to″ vizsg{\'a}lat",
abstract = "Dipeptidyl peptidase-4 (DPP-4) has an important role in the carbohydrate metabolism with the degradation of incretin hormones. Aim: We assessed the serum DPP-4 activity both in fasting and postprandial condition in patients with type 1-, type 2 diabetes and healthy controls. Methods: Serum DPP-4 activities were determined at fasting sate and at 60 and 180 minutes after test meal. DPP-4 activity was measured by microplate-based kinetic assay in 41 type 1-, and in 87 type 2 diabetic patients and in 25 healthy volunteers. Results: Serum DPP-4 activities were found significantly higher both in fasting and postprandial state in patients with type 1 diabetes than in type 2 and control subjects. No change in the enzyme activities was found after test meal. Correlation was neither detected between the fasting plasma glucose nor between the HbA 1C and the DPP-4 values in any of the groups studied. Conclusions: Results suggest that it is not the hyperglycemia, rather the type of diabetes which determinates the serum DPP-4 enzymatic activity. The exact background of this phenomenon is not yet clear, however, increased serum DPP-4 enzyme activity in type 1 diabetes mellitus may refer to pancreatic autoimmune process, concomitant autoimmune diseases, hormonal feed back mechanism, or even target organ damage.",
keywords = "1-es t{\'i}pus{\'u} cukorbetegs{\'e}g, 2-es t{\'i}pus{\'u} cukorbetegs{\'e}g, Autoimmunit{\'a}s, Autoimmunity, Dipeptidil-peptid{\'a}z-4, Dipeptidyl peptidase-4, Glucagon-like peptide-1, Glucose dependent insulinotropic polypeptide, Type 1 diabetes mellitus, Type 2 diabetes mellitus",
author = "T{\'i}mea Varga and G. Firneisz and G{\'e}za Nagy and A. Somogyi",
year = "2010",
month = "5",
day = "1",
doi = "10.1556/OH.2010.28842",
language = "Hungarian",
volume = "151",
pages = "899--902",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "22",

}

TY - JOUR

T1 - Emelkedett szérum-dipeptidil-peptidáz-4 enzimaktivitá sa 1-es típusú diabetesben

T2 - összehasonlíto″ vizsgálat

AU - Varga, Tímea

AU - Firneisz, G.

AU - Nagy, Géza

AU - Somogyi, A.

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Dipeptidyl peptidase-4 (DPP-4) has an important role in the carbohydrate metabolism with the degradation of incretin hormones. Aim: We assessed the serum DPP-4 activity both in fasting and postprandial condition in patients with type 1-, type 2 diabetes and healthy controls. Methods: Serum DPP-4 activities were determined at fasting sate and at 60 and 180 minutes after test meal. DPP-4 activity was measured by microplate-based kinetic assay in 41 type 1-, and in 87 type 2 diabetic patients and in 25 healthy volunteers. Results: Serum DPP-4 activities were found significantly higher both in fasting and postprandial state in patients with type 1 diabetes than in type 2 and control subjects. No change in the enzyme activities was found after test meal. Correlation was neither detected between the fasting plasma glucose nor between the HbA 1C and the DPP-4 values in any of the groups studied. Conclusions: Results suggest that it is not the hyperglycemia, rather the type of diabetes which determinates the serum DPP-4 enzymatic activity. The exact background of this phenomenon is not yet clear, however, increased serum DPP-4 enzyme activity in type 1 diabetes mellitus may refer to pancreatic autoimmune process, concomitant autoimmune diseases, hormonal feed back mechanism, or even target organ damage.

AB - Dipeptidyl peptidase-4 (DPP-4) has an important role in the carbohydrate metabolism with the degradation of incretin hormones. Aim: We assessed the serum DPP-4 activity both in fasting and postprandial condition in patients with type 1-, type 2 diabetes and healthy controls. Methods: Serum DPP-4 activities were determined at fasting sate and at 60 and 180 minutes after test meal. DPP-4 activity was measured by microplate-based kinetic assay in 41 type 1-, and in 87 type 2 diabetic patients and in 25 healthy volunteers. Results: Serum DPP-4 activities were found significantly higher both in fasting and postprandial state in patients with type 1 diabetes than in type 2 and control subjects. No change in the enzyme activities was found after test meal. Correlation was neither detected between the fasting plasma glucose nor between the HbA 1C and the DPP-4 values in any of the groups studied. Conclusions: Results suggest that it is not the hyperglycemia, rather the type of diabetes which determinates the serum DPP-4 enzymatic activity. The exact background of this phenomenon is not yet clear, however, increased serum DPP-4 enzyme activity in type 1 diabetes mellitus may refer to pancreatic autoimmune process, concomitant autoimmune diseases, hormonal feed back mechanism, or even target organ damage.

KW - 1-es típusú cukorbetegség

KW - 2-es típusú cukorbetegség

KW - Autoimmunitás

KW - Autoimmunity

KW - Dipeptidil-peptidáz-4

KW - Dipeptidyl peptidase-4

KW - Glucagon-like peptide-1

KW - Glucose dependent insulinotropic polypeptide

KW - Type 1 diabetes mellitus

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=77952755033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952755033&partnerID=8YFLogxK

U2 - 10.1556/OH.2010.28842

DO - 10.1556/OH.2010.28842

M3 - Article

VL - 151

SP - 899

EP - 902

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 22

ER -