Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance

Eva Palik, Eva Baranyi, Zsolt Melczer, Maria Audikovszky, Albert Szöcs, Gábor Winkler, Károly Cseh

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Aim: To study fasting biologically active serum ghrelin (RIA) and resistin (ELISA) levels in different trimesters of pregnancy (HP, n = 45, 15 in each) and in gestational diabetes mellitus (GDM, n = 30) compared to non-pregnant healthy women (NP, n = 40) in correlation with TNF-α, soluble (s)TNF-receptor (R)-1, -2, leptin (ELISA), C-peptide (Cp, RIA) and Cp/blood glucose ratio (bg). Study design: Cross-sectional case control study. Results: Acylated ghrelin levels were significantly increased (p < 0.0001) in the 2nd (377 ± 38 pg/ml, X ± S.D.) and decreased in the 3rd trimester (252 ± 36) and in GDM (226 ± 21) compared to NP controls (309 ± 20) and HP women in the 1st trimester (314 ± 41). Serum resistin levels were higher in the 1st (8.5 ± 2.6 ng/ml), 2nd (10.2 ± 2.1) and 3rd (13.1 ± 3.6) trimesters of pregnancy and in GDM (15.7 ± 3.5) than in NP controls (6.5 ± 2.3). Significant (p < 0.01) negative linear correlations were found among fasting serum ghrelin and body mass index (BMI), the fasting C-peptide (Cp) level, C-peptide/blood glucose (Cp/bg) ratio, TNF-α, soluble (s)TNFR-2, leptin and resistin concentrations in both, HP and GDM groups. Significant positive correlations were observed between serum acylated ghrelin and adiponectin, and between BMI and fasting Cp, Cp/bg, TNF-α, sTNFR-1, -2 and leptin levels in both pregnant groups. Conclusion: Increased fasting serum acylated ghrelin concentrations in the 2nd trimester may associate with weight gain during pregnancy. Hyperresistinemia may also be associated with the pregnancy-induced insulin resistance. A negative regulatory feed-back mechanism between resistin, TNF-α and ghrelin may be hypothesized.

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalDiabetes Research and Clinical Practice
Issue number3
Publication statusPublished - Jun 1 2007



  • Cytokines
  • Gestational diabetes mellitus
  • Ghrelin
  • Insulin resistance
  • Pregnancy
  • Resistin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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