Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance

Eva Palik, Eva Baranyi, Zsolt Melczer, Maria Audikovszky, Albert Szöcs, G. Winkler, K. Cseh

Research output: Contribution to journalArticle

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Abstract

Aim: To study fasting biologically active serum ghrelin (RIA) and resistin (ELISA) levels in different trimesters of pregnancy (HP, n = 45, 15 in each) and in gestational diabetes mellitus (GDM, n = 30) compared to non-pregnant healthy women (NP, n = 40) in correlation with TNF-α, soluble (s)TNF-receptor (R)-1, -2, leptin (ELISA), C-peptide (Cp, RIA) and Cp/blood glucose ratio (bg). Study design: Cross-sectional case control study. Results: Acylated ghrelin levels were significantly increased (p <0.0001) in the 2nd (377 ± 38 pg/ml, X ± S.D.) and decreased in the 3rd trimester (252 ± 36) and in GDM (226 ± 21) compared to NP controls (309 ± 20) and HP women in the 1st trimester (314 ± 41). Serum resistin levels were higher in the 1st (8.5 ± 2.6 ng/ml), 2nd (10.2 ± 2.1) and 3rd (13.1 ± 3.6) trimesters of pregnancy and in GDM (15.7 ± 3.5) than in NP controls (6.5 ± 2.3). Significant (p <0.01) negative linear correlations were found among fasting serum ghrelin and body mass index (BMI), the fasting C-peptide (Cp) level, C-peptide/blood glucose (Cp/bg) ratio, TNF-α, soluble (s)TNFR-2, leptin and resistin concentrations in both, HP and GDM groups. Significant positive correlations were observed between serum acylated ghrelin and adiponectin, and between BMI and fasting Cp, Cp/bg, TNF-α, sTNFR-1, -2 and leptin levels in both pregnant groups. Conclusion: Increased fasting serum acylated ghrelin concentrations in the 2nd trimester may associate with weight gain during pregnancy. Hyperresistinemia may also be associated with the pregnancy-induced insulin resistance. A negative regulatory feed-back mechanism between resistin, TNF-α and ghrelin may be hypothesized.

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume76
Issue number3
DOIs
Publication statusPublished - Jun 2007

Fingerprint

Resistin
Ghrelin
C-Peptide
Weight Gain
Insulin Resistance
Pregnancy
Fasting
Serum
Leptin
Pregnancy Trimesters
Blood Glucose
Body Mass Index
Enzyme-Linked Immunosorbent Assay
Gestational Diabetes
Tumor Necrosis Factor Receptors
Adiponectin
Case-Control Studies
Cross-Sectional Studies
polypeptide C

Keywords

  • Cytokines
  • Gestational diabetes mellitus
  • Ghrelin
  • Insulin resistance
  • Pregnancy
  • Resistin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance. / Palik, Eva; Baranyi, Eva; Melczer, Zsolt; Audikovszky, Maria; Szöcs, Albert; Winkler, G.; Cseh, K.

In: Diabetes Research and Clinical Practice, Vol. 76, No. 3, 06.2007, p. 351-357.

Research output: Contribution to journalArticle

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abstract = "Aim: To study fasting biologically active serum ghrelin (RIA) and resistin (ELISA) levels in different trimesters of pregnancy (HP, n = 45, 15 in each) and in gestational diabetes mellitus (GDM, n = 30) compared to non-pregnant healthy women (NP, n = 40) in correlation with TNF-α, soluble (s)TNF-receptor (R)-1, -2, leptin (ELISA), C-peptide (Cp, RIA) and Cp/blood glucose ratio (bg). Study design: Cross-sectional case control study. Results: Acylated ghrelin levels were significantly increased (p <0.0001) in the 2nd (377 ± 38 pg/ml, X ± S.D.) and decreased in the 3rd trimester (252 ± 36) and in GDM (226 ± 21) compared to NP controls (309 ± 20) and HP women in the 1st trimester (314 ± 41). Serum resistin levels were higher in the 1st (8.5 ± 2.6 ng/ml), 2nd (10.2 ± 2.1) and 3rd (13.1 ± 3.6) trimesters of pregnancy and in GDM (15.7 ± 3.5) than in NP controls (6.5 ± 2.3). Significant (p <0.01) negative linear correlations were found among fasting serum ghrelin and body mass index (BMI), the fasting C-peptide (Cp) level, C-peptide/blood glucose (Cp/bg) ratio, TNF-α, soluble (s)TNFR-2, leptin and resistin concentrations in both, HP and GDM groups. Significant positive correlations were observed between serum acylated ghrelin and adiponectin, and between BMI and fasting Cp, Cp/bg, TNF-α, sTNFR-1, -2 and leptin levels in both pregnant groups. Conclusion: Increased fasting serum acylated ghrelin concentrations in the 2nd trimester may associate with weight gain during pregnancy. Hyperresistinemia may also be associated with the pregnancy-induced insulin resistance. A negative regulatory feed-back mechanism between resistin, TNF-α and ghrelin may be hypothesized.",
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T1 - Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance

AU - Palik, Eva

AU - Baranyi, Eva

AU - Melczer, Zsolt

AU - Audikovszky, Maria

AU - Szöcs, Albert

AU - Winkler, G.

AU - Cseh, K.

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N2 - Aim: To study fasting biologically active serum ghrelin (RIA) and resistin (ELISA) levels in different trimesters of pregnancy (HP, n = 45, 15 in each) and in gestational diabetes mellitus (GDM, n = 30) compared to non-pregnant healthy women (NP, n = 40) in correlation with TNF-α, soluble (s)TNF-receptor (R)-1, -2, leptin (ELISA), C-peptide (Cp, RIA) and Cp/blood glucose ratio (bg). Study design: Cross-sectional case control study. Results: Acylated ghrelin levels were significantly increased (p <0.0001) in the 2nd (377 ± 38 pg/ml, X ± S.D.) and decreased in the 3rd trimester (252 ± 36) and in GDM (226 ± 21) compared to NP controls (309 ± 20) and HP women in the 1st trimester (314 ± 41). Serum resistin levels were higher in the 1st (8.5 ± 2.6 ng/ml), 2nd (10.2 ± 2.1) and 3rd (13.1 ± 3.6) trimesters of pregnancy and in GDM (15.7 ± 3.5) than in NP controls (6.5 ± 2.3). Significant (p <0.01) negative linear correlations were found among fasting serum ghrelin and body mass index (BMI), the fasting C-peptide (Cp) level, C-peptide/blood glucose (Cp/bg) ratio, TNF-α, soluble (s)TNFR-2, leptin and resistin concentrations in both, HP and GDM groups. Significant positive correlations were observed between serum acylated ghrelin and adiponectin, and between BMI and fasting Cp, Cp/bg, TNF-α, sTNFR-1, -2 and leptin levels in both pregnant groups. Conclusion: Increased fasting serum acylated ghrelin concentrations in the 2nd trimester may associate with weight gain during pregnancy. Hyperresistinemia may also be associated with the pregnancy-induced insulin resistance. A negative regulatory feed-back mechanism between resistin, TNF-α and ghrelin may be hypothesized.

AB - Aim: To study fasting biologically active serum ghrelin (RIA) and resistin (ELISA) levels in different trimesters of pregnancy (HP, n = 45, 15 in each) and in gestational diabetes mellitus (GDM, n = 30) compared to non-pregnant healthy women (NP, n = 40) in correlation with TNF-α, soluble (s)TNF-receptor (R)-1, -2, leptin (ELISA), C-peptide (Cp, RIA) and Cp/blood glucose ratio (bg). Study design: Cross-sectional case control study. Results: Acylated ghrelin levels were significantly increased (p <0.0001) in the 2nd (377 ± 38 pg/ml, X ± S.D.) and decreased in the 3rd trimester (252 ± 36) and in GDM (226 ± 21) compared to NP controls (309 ± 20) and HP women in the 1st trimester (314 ± 41). Serum resistin levels were higher in the 1st (8.5 ± 2.6 ng/ml), 2nd (10.2 ± 2.1) and 3rd (13.1 ± 3.6) trimesters of pregnancy and in GDM (15.7 ± 3.5) than in NP controls (6.5 ± 2.3). Significant (p <0.01) negative linear correlations were found among fasting serum ghrelin and body mass index (BMI), the fasting C-peptide (Cp) level, C-peptide/blood glucose (Cp/bg) ratio, TNF-α, soluble (s)TNFR-2, leptin and resistin concentrations in both, HP and GDM groups. Significant positive correlations were observed between serum acylated ghrelin and adiponectin, and between BMI and fasting Cp, Cp/bg, TNF-α, sTNFR-1, -2 and leptin levels in both pregnant groups. Conclusion: Increased fasting serum acylated ghrelin concentrations in the 2nd trimester may associate with weight gain during pregnancy. Hyperresistinemia may also be associated with the pregnancy-induced insulin resistance. A negative regulatory feed-back mechanism between resistin, TNF-α and ghrelin may be hypothesized.

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KW - Gestational diabetes mellitus

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KW - Insulin resistance

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