Elevated sera levels of sp-1 induced by chemotherapy in patients with metastatic gestational trophoblastic diseases

P. M. Göcze, G. N. Than, D. G. Szabò, I. F. Csaba, H. Bohn

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3 Citations (Scopus)

Abstract

6 patients with invasive mole and 5 patients with choriocarcinoma were treated from 1983 till 1986. Serum samples were analyzed by simultaneous determining of pregnancy-specific beta-1-glycoprotein (SP-1) using enzyme-linked immunosorbent assay (ELISA) and beta subunit of human chorionic gonadotropin (ß-hCG) using Serono radioimmunoassay kit. In 2 patients with metastatic gestational trophoblastic disease (MGTD) SP-1 peaks were found during chemotherapy. In patients with MGTD with normalized ß-hCG levels a repeated, temporary elevation of isolated SP-1 levels was observed within some months following chemotherapy. After the last isolated peak of SP-1 the pulmonary metastases disappeared. This phenomenon was interpreted as a consequence of the oncolytic process in the affected tissue. In 1 patient with nonmetastatic choriocarcinoma SP-1 ELISA pseudoreaction was found. To recognize these pseudoreactions, a control plate with nonimmunized rabbit IgG was used, simultaneously with SP-1 determinations.

Original languageEnglish
Pages (from-to)406-409
Number of pages4
JournalOncology (Switzerland)
Volume47
Issue number5
DOIs
Publication statusPublished - Jan 1 1990

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Keywords

  • Chemotherapy
  • Gestational trophoblastic disease
  • Isolated SP-1 elevation
  • Oncolysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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