Elevated plasma nociceptin level in patients with Wilson disease

M. Hantos, F. Szalay, P. Lakatos, Dalma Hegedus, G. Firneisz, J. Reiczigel, Tamás Török, K. Tekes

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Plasma level of nociceptin, the endogenous agonist of orphanin FQ/ORL1 receptor was found to be significantly elevated in Wilson disease patients (13.98±2.44pg/ml, p125I-radioimmunoassay. Neither sex differences nor correlation between plasma nociceptin levels and liver function test results were found. It is suggested that elevated plasma nociceptin level found in Wilson disease patients is due to inhibition of nociceptin-inactivating Zn-metallopeptidases (aminopeptidase N (APN) and endopeptidase 24.15) by the toxic copper deposits in liver and/or brain.

Original languageEnglish
Pages (from-to)311-313
Number of pages3
JournalBrain Research Bulletin
Volume58
Issue number3
DOIs
Publication statusPublished - 2002

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Hepatolenticular Degeneration
thimet oligopeptidase
CD13 Antigens
Poisons
Liver Function Tests
Metalloproteases
Sex Characteristics
Radioimmunoassay
Copper
nociceptin
Liver
Brain
nociceptin receptor

Keywords

  • Aminopeptidase N
  • Endopeptidase 24.15.
  • Liver
  • Nociceptin
  • Wilson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Elevated plasma nociceptin level in patients with Wilson disease. / Hantos, M.; Szalay, F.; Lakatos, P.; Hegedus, Dalma; Firneisz, G.; Reiczigel, J.; Török, Tamás; Tekes, K.

In: Brain Research Bulletin, Vol. 58, No. 3, 2002, p. 311-313.

Research output: Contribution to journalArticle

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AU - Reiczigel, J.

AU - Török, Tamás

AU - Tekes, K.

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