Elevated monocyte interleukin-6 (IL-6) production in immunosuppressed trauma patients. II. Downregulation by IL-4

Gyongyi Szabo, Karen Kodys, Carol L. Miller-Graziano

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Aberrant monocyte mediator production is pivotal in the development of posttrauma immunosuppression. We have previously shown that immunodepressed trauma patients' monocytes produce elevated interleukin-6, suggesting their in vivo preactivation. This study confirms that preactivated patients' MØ produce greater levels of IL-6 than normals' MØ to the same in vitro FcγRI stimulation. We also demonstrate the capacity of interleukin-4 to downregulate the elevated interleukin-6 production of trauma patients'in vivo preactivated monocytes. Monocyte interleukin-6 downregulation by interleukin-4 is dose dependent and occurs whether FcγRI cross-linking, muramyl dipeptide, indomethacin plus muramyl dipeptide, or interferon-gamma plus muramyl dipeptide is the interleukin-6 inducing stimulus. Furthermore, interleukin-4-dependent downregulation of monocyte interleukin-6 expression is confirmed at both the supernatant and the mRNA levels. Simultaneous downregulation of posttrauma elevated monokines implies a possible therapeutic benefit of interleukin-4 for trauma patients.

Original languageEnglish
Pages (from-to)336-344
Number of pages9
JournalJournal of Clinical Immunology
Volume11
Issue number6
DOIs
Publication statusPublished - Nov 1 1991

Keywords

  • FcRI receptor
  • immunomodulation
  • interleukin-4
  • prostaglandin E
  • tumor necrosis factor alpha

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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