Elevated levels of inflammatory biomarkers in the cerebrospinal fluid after coronary artery bypass surgery are predictors of cognitive decline

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Abstract

Recovery from cardiac surgery is marred for many patients by the development of neurological, psychological or cognitive dysfunction. An uncontrolled inflammatory reaction, in response to surgical stress, may be responsible. To confirm this hypothesis, the present study evaluated changes in the levels of cytokines in cerebrospinal fluid after coronary artery bypass grafting. One week post-operatively, the concentration of the pro-inflammatory cytokine interleukin-6 markedly increased; 6 months after surgery, however, its level normalized with an increased concentration of the anti-inflammatory interleukin-4. This suggests that a regulated immune response may participate in developing adverse neurologic events and complications following cardiac interventions, and cytokines in the cerebrospinal fluid may serve as specific biomarkers and predictors of developing cognitive decline after coronary surgery.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalNeurochemistry international
Volume48
Issue number3
DOIs
Publication statusPublished - Feb 1 2006

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Keywords

  • Alzheimer's disease
  • Biomarker
  • Cardiac surgery
  • Cerebral injury
  • Cerebrospinal fluid
  • Cognitive function
  • Cytokine
  • ELISA
  • IL-1β
  • IL-4
  • IL-6
  • Inflammation
  • Interleukin
  • Neuropathology
  • S100β

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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