Elevated levels of asymmetric dimethylarginine (ADMA) in the pericardial fluid of cardiac patients correlate with cardiac hypertrophy

Zoltan Nemeth, Attila Cziraki, Sandor Szabados, Bernadett Biri, Sandor Keki, Akos Koller

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Pericardial fluid (PF) contains several biologically active substances, which may provide information regarding the cardiac conditions. Nitric oxide (NO) has been implicated in cardiac remodeling. We hypothesized that L-arginine (L-Arg) precursor of NO-synthase (NOS) and asymmetric dimethylarginine (ADMA), an inhibitor of NOS, are present in PF of cardiac patients and their altered levels may cont ribute to altered cardiac morphology. Methods L-Arg and ADMA concentrations in plasma and PF, and echocardiographic parameters of patients undergoing coronary artery bypass graft (CABG, n=28) or valve replacement (VR, n=25) were determined. Results We have found LV hypertrophy in 35.7% of CABG, and 80%of VR patients. In all groups, plasma and PF L-Arg levels were higher than that of ADMA. Plasma L-Arg level was higher in CABG than VR (75.7±4.6 μmol/L vs. 58.1±4.9 μmol/L, p=0.011), whereas PF ADMA level was higher in VR than CABG (0.9±0.0 μmol/L vs. 0.7±0.0 μmol/L, p=0.009). L-Arg/ADMA ratio was lower in the VR than CABG (VRplasma: 76.1±6.6 vs. CABGplasma: 125.4±10.7, p=0.004; VRPF: 81.7±4.8 vs. CABGPF: 110.4±7.2, p=0.009). There was a positive correlation between plasma L-Arg and ADMA in CABG (r=0.539, p=0.015); and plasma and PF L-Arg in CABG (r=0.357, p=0.031); and plasma and PF ADMA in VR (r=0.529, p=0.003); and PF L-Arg and ADMA in both CABG and VR (CABG: r=0.468, p=0.006; VR: r=0.371, p=0.034). The following echocardiographic parameters wer e higher in VR compared toCABG: interventricular septum (14.7±0.5mm vs. 11.9±0.4mm, p=0.000); posterior wall thickness (12.6±0.3 mm vs. 11.5±0.2 mm, p=0.000); left ventricular (LV) mass (318.6±23.5 g vs. 234.6±12.3 g, p=0.007); right ventricular (RV) (33.9±0.9 cm2 vs. 29.7±0.7 cm2, p=0.004); right atrial (18.6±1.0 cm2 vs. 15.4±0.6 cm2, p=0.020); left atrial (19.8±1.0 cm2 vs. 16.9±0.6 cm2, p=0.033) areas. There was a positive correlation between plasma ADMA and RV area (r=0.453, p=0.011); PF ADMA and end-diastolic (r=0.434, p=0.015) and systolic diameter of LV (r=0.487, p=0.007); and negative correlation between PF ADMA and LV ejection fraction (r=-0.445, p=0.013) in VR. Conclusion We suggest that elevated levels of ADMA in the PF of patients indicate upregulated RAS and reduced bioavailability of NO, which can contribute to the development of cardiac hypertrophy and remodeling.

Original languageEnglish
Article numbere0135498
JournalPloS one
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 27 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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