Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function

Katalin Réka Kovács, Zoltán Bajkó, Csilla Cecília Szekeres, Krisztina Csapó, L. Oláh, M. Magyar, Sándor Molnár, Dániel Czuriga, László Kardos, Andrea Bojtor Burainé, D. Bereczki, P. Soltész, L. Csiba

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hypertension and dyslipidemia belong to the most prevalent modifiable risk factors for cerebrovascular and cardiovascular diseases. Hereby, we aimed to examine the combined effects of newly diagnosed hypertension and hyperlipidemia on the characteristics of the arterial wall and on cognitive function. We examined 72 hypertensive and 85 apparently healthy individuals. Based on serum lipid levels, four subgroups were created ranging from normotensive- normolipidemic to hypertensive-hyperlipidemic subjects. Carotid intima-media thickness (IMT), arterial stiffness, and cognitive function were assessed. IMT of controls was the lowest, whereas that of patients with both risk factors the highest. Stiffness parameters increased when both risk factors were present, whereas subjects with only one risk factor exhibited intermediate values. Hypertensive patients performed worse when memory, attention, reaction time, and trait anxiety were assessed. Significant worsening of IMT, arterial stiffness, and sum of neuropsychological scores was observed along with increasing mean arterial pressure. Generally, hyperlipidemia combining with hypertension resulted in further worsening of all examined parameters. Subclinical changes of the vascular wall and cognitive performance are already present in recently diagnosed hypertensive patients. Combination of hyperlipidemia and hypertension results in more severe impairments, therefore, early and intensive treatment may be crucial to prevent further deterioration.

Original languageEnglish
Pages (from-to)550-560
Number of pages11
JournalJournal of the American Society of Hypertension
Volume8
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Cognition
Blood Vessels
Hyperlipidemias
Hypertension
Vascular Stiffness
Cerebrovascular Disorders
Carotid Intima-Media Thickness
Dyslipidemias
Reaction Time
Arterial Pressure
Cardiovascular Diseases
Anxiety
Lipids
oxidized low density lipoprotein
Serum
Therapeutics

Keywords

  • Arterial stiffness
  • cardiovascular risk factors
  • intima-media thickness
  • neuropsychological performance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function. / Kovács, Katalin Réka; Bajkó, Zoltán; Szekeres, Csilla Cecília; Csapó, Krisztina; Oláh, L.; Magyar, M.; Molnár, Sándor; Czuriga, Dániel; Kardos, László; Burainé, Andrea Bojtor; Bereczki, D.; Soltész, P.; Csiba, L.

In: Journal of the American Society of Hypertension, Vol. 8, No. 8, 2014, p. 550-560.

Research output: Contribution to journalArticle

Kovács, Katalin Réka ; Bajkó, Zoltán ; Szekeres, Csilla Cecília ; Csapó, Krisztina ; Oláh, L. ; Magyar, M. ; Molnár, Sándor ; Czuriga, Dániel ; Kardos, László ; Burainé, Andrea Bojtor ; Bereczki, D. ; Soltész, P. ; Csiba, L. / Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function. In: Journal of the American Society of Hypertension. 2014 ; Vol. 8, No. 8. pp. 550-560.
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