Element status of total blood and redox homeostasis of phlebotomized sporadic porphyria cutanea tarda patients with diabetes mellitus and in heavy drinkers

E. Székely, K. Szentmihályi, G. Tasnádi, T. Kurucz, Z. Pallai, A. Somogyi, A. Blázovics

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Abstract

Sporadic porphyria cutanea tarda (PCT) is a disorder of heme biosynthesis due to reduced activity of the uroporphyrinogen decarboxylase enzyme. Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation resulted in cirrhosis. The total blood of 33 male patients (7 patients with PCT, 10 PCT patients with alcohol consumption, 6 PCT patients with alcohol consumption and type 2 diabetes mellitus and 10 male volunteers of Caucasian origin) were analyzed. Routine laboratory serum parameters and urine UP, H-donating ability, reducing power, plasma-free SH group concentration, stimulated chemiluminescent intensity of plasma and erythrocyte chemiluminescent intensity superoxide dismutase (SOD), and glutathione peroxidase (SGH-Px) activities were determined. K concentration in PCT patients, S concentration in alcohol consumer PCT patients and Mg and Zn concentration in alcohol consumer PCT patients with type 2 diabetes mellitus decreased significantly (p ≤ 0.05) compared to the controls. The concentrations of Cu, Fe, Mn and P did not differ significantly in phlebotomized patient groups compared to the control, although Cu concentration was elevated and the other elements were lower in PCT groups. Metabolic alterations and alterations in the free radical antioxidant balance were found to be in close correlation with the severity of the illness. Phlebotomy generally contributes to normalizing element concentration in the blood of PCT patients, although some alterations could still be detected. The decreased concentrations of Mg, Zn, K, S, P and Mn in the total blood and low H-donating ability, SOD and GSH-Px, as well as total scavenger capacity of the plasma may contribute to cutaneous reaction, skin fragility, blisters in areas exposed to the sun and to cirrhotic processes in the liver, especially in diabetic PCT patients.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalTrace Elements and Electrolytes
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 1 2006

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Keywords

  • Element analysis
  • PCT
  • Redox homeostasis
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Inorganic Chemistry

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