Eleganketal a, a highly oxygenated dibenzospiroketal from the marine-derived fungus Spicaria elegans KLA03

Yepeng Luan, Hongjuan Wei, Zhenpei Zhang, Qian Che, Yankai Liu, Tianjiao Zhu, Attila Mándi, T. Kurtán, Qianqun Gu, Dehai Li

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Eleganketal A (1), a naturally occurring aromatic polyketide possessing a rare highly oxygenated spiro[isobenzofuran-1,3′-isochroman] ring system, was isolated from the fungus Spicaria elegans KLA03 by culturing it in a modified mannitol-based medium. The structure of 1 including the absolute configuration was determined by combining spectroscopic analysis, synthesis of the racemic permethylated analogue, chiral-phase HPLC separation, and TDDFT-ECD analysis.

Original languageEnglish
Pages (from-to)1718-1723
Number of pages6
JournalJournal of Natural Products
Volume77
Issue number7
DOIs
Publication statusPublished - Jul 25 2014

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Polyketides
Spectroscopic analysis
Mannitol
Fungi
Phase separation
High Pressure Liquid Chromatography
eleganketal A

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

Cite this

Eleganketal a, a highly oxygenated dibenzospiroketal from the marine-derived fungus Spicaria elegans KLA03. / Luan, Yepeng; Wei, Hongjuan; Zhang, Zhenpei; Che, Qian; Liu, Yankai; Zhu, Tianjiao; Mándi, Attila; Kurtán, T.; Gu, Qianqun; Li, Dehai.

In: Journal of Natural Products, Vol. 77, No. 7, 25.07.2014, p. 1718-1723.

Research output: Contribution to journalArticle

Luan, Y, Wei, H, Zhang, Z, Che, Q, Liu, Y, Zhu, T, Mándi, A, Kurtán, T, Gu, Q & Li, D 2014, 'Eleganketal a, a highly oxygenated dibenzospiroketal from the marine-derived fungus Spicaria elegans KLA03', Journal of Natural Products, vol. 77, no. 7, pp. 1718-1723. https://doi.org/10.1021/np500458a
Luan, Yepeng ; Wei, Hongjuan ; Zhang, Zhenpei ; Che, Qian ; Liu, Yankai ; Zhu, Tianjiao ; Mándi, Attila ; Kurtán, T. ; Gu, Qianqun ; Li, Dehai. / Eleganketal a, a highly oxygenated dibenzospiroketal from the marine-derived fungus Spicaria elegans KLA03. In: Journal of Natural Products. 2014 ; Vol. 77, No. 7. pp. 1718-1723.
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