Electrospun water soluble polymer mat for ultrafast release of donepezil HCL

Z. K. Nagy, K. Nyúl, I. Wagner, K. Molnár, G. Marosi

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Electrostatic spinning (Electrospinning, ES) was applied to prepare Donepezil HCl loaded nanofibers as a potential orally dissolving dosage form. Electrospinning of water solutions of different polymers were performed in order to fabricate a consistent and removable web on the collector with ultra-fast dissolution in water based media. Poly(vinyl-alcohol) of low molecular weight was found to be the most appropriate for this purpose. Morphology of the prepared nanofibers was characterized by scanning electron microscope as a function of viscosity and drug content. Diameters of the fibers were between 100 and 300 nm with narrow distribution. In vitro drug release of the webs was immediate (less than 30 s) after immersion independently of their drug content owing to the formed huge surface area, while cast films with the same compositions and commercial tablets needed 30 min or more for complete dissolution. The developed technology for the preparation of orally dissolving web (ODW) formulations is a promising way for producing effective and acceptable dosage forms for children, older people and patients with dysphagia.

Original languageEnglish
Pages (from-to)763-772
Number of pages10
JournalExpress Polymer Letters
Volume4
Issue number12
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Electrospinning
Nanofibers
Polymers
dissolving
Dissolution
Dosage Forms
drugs
Water
polymers
Pharmaceutical Preparations
water
Electrostatics
Alcohols
Electron microscopes
Molecular weight
Viscosity
Scanning
dosage
Tablets
tablets

Keywords

  • Drug delivery
  • Electrospinning
  • Nanomaterials
  • Orally dissolving web (ODW)
  • Ultrafast dissolution

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry
  • Chemical Engineering(all)
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Electrospun water soluble polymer mat for ultrafast release of donepezil HCL. / Nagy, Z. K.; Nyúl, K.; Wagner, I.; Molnár, K.; Marosi, G.

In: Express Polymer Letters, Vol. 4, No. 12, 12.2010, p. 763-772.

Research output: Contribution to journalArticle

Nagy, Z. K. ; Nyúl, K. ; Wagner, I. ; Molnár, K. ; Marosi, G. / Electrospun water soluble polymer mat for ultrafast release of donepezil HCL. In: Express Polymer Letters. 2010 ; Vol. 4, No. 12. pp. 763-772.
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