Electrospun poly(aspartic acid) gel scaffolds for artificial extracellular matrix

Kristof Molnar, David Juriga, Peter M. Nagy, Katalin Sinko, Angela Jedlovszky-Hajdu, Miklos Zrinyi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Biocompatible synthetic polymer scaffolds for tissue engineering and regenerative medicine were prepared using reactive electrospinning. Fibrous poly(aspartic acid) gels with size similar to that of extracellular matrix were obtained. Biocompatible synthetic polymer gel scaffolds for tissue engineering and regenerative medicine were prepared by reactive electrospinning. Protein-like nano- and microfibres from chemically crosslinked polysuccinimide were obtained. Fibrous poly(aspartic acid) gels with size similar to that of extracellular matrix were obtained by hydrolysis of the polysuccinimide gel fibres. The effects of process parameters on fibre morphology (diameter, swelling degree) and chemical structure were investigated. Sub-micrometre-sized biocompatible fibrous scaffolds from a poly(amino acid) is a novel approach with great promise in several biomedical applications due to the tailor-made synthetic nature, extreme purity and possibility of production on a large scale.

Original languageEnglish
Pages (from-to)1608-1615
Number of pages8
JournalPolymer International
Volume63
Issue number9
DOIs
Publication statusPublished - Sep 2014

    Fingerprint

Keywords

  • Artificial extracellular matrix
  • Poly(aspartic acid)
  • Polysuccinimide
  • Reactive electrospinning
  • Tissue engineering

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this