Electrospun nanofiber-based niflumic acid capsules with superior physicochemical properties

Norbert Radacsi, Konstantinos P. Giapis, George Ovari, Piroska Szabó-Révész, Rita Ambrus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of this study was to assess whether nanofibrous drug mats have potential as delivery systems for poorly water-soluble drugs. Amorphous nanofiber mats from a model poorly water-soluble active pharmaceutical ingredient (API), niflumic acid, together with the polymer excipient, polyvinyl pyrrolidine, were prepared by nozzle-free electrospinning. This technique offers a scalable way for drug formulation, and by increasing the surface area of the drug, the dissolution rate and therefore bioavailability of the API can be improved. In this study, both the amount of the dissolved active ingredient and the dissolution kinetics has been improved significantly when the nanofibrous mats were used in the drug formulation. A 15-fold increase in the dissolved amount of the produced amorphous niflumic acid nanofiber was observed compared to the dissolved amount of the raw drug within the first 15 min. Capsule formulation was made by mixing the electrospun nanofibers with a microcrystalline cellulose filler agent. When comparing the dissolution rate of the capsule formulation on the market with the nanofibrous capsules, a 14-fold increase was observed in the dissolved drug amount within the first 15 min.

Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume166
DOIs
Publication statusPublished - Mar 20 2019

Keywords

  • Amorphous solid dispersion
  • Electrospinning
  • Niflumic acid
  • Physicochemical analysis
  • Poorly water-soluble drug

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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