Electrophysiological study on the high K+ sensitivity of rat glomerulosa cells

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Abstract

Elevation of extracellular potassium concentration by as little as some tenth of mM activates rat adrenal glomerulosa cells. In the present study some factors responsible for this high K+ sensitivity were examined. Using whole-cell voltage-clamp technique we found that both T-type and L-type voltage-dependent Ca2+ channels have very low threshold potential (-71 and -58 mV, resp.). By means of patch-clamp technique combined with single-cell fluorimetry we also provided evidence that the activation of I(gl), a K+-activated inward rectifying current is associated with Ca2+ influx. Both the low activation threshold of voltage-dependent Ca2+ channels and the function of I(gl) contribute to the exceptional K+ sensitivity of the glomerulosa cells.

Original languageEnglish
Pages (from-to)429-431
Number of pages3
JournalPflugers Archiv European Journal of Physiology
Volume435
Issue number3
DOIs
Publication statusPublished - Feb 18 1998

Keywords

  • Calcium channel
  • Calcium signal
  • Glomerulosa
  • Patch-clamp
  • Potassium

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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