Electrophysiological study on the high K+ sensitivity of rat glomerulosa cells

P. Várnai, G. Petheö, Judit K. Makara, A. Spät

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Elevation of extracellular potassium concentration by as little as some tenth of mM activates rat adrenal glomerulosa cells. In the present study some factors responsible for this high K+ sensitivity were examined. Using whole-cell voltage-clamp technique we found that both T-type and L-type voltage-dependent Ca2+ channels have very low threshold potential (-71 and -58 mV, resp.). By means of patch-clamp technique combined with single-cell fluorimetry we also provided evidence that the activation of I(gl), a K+-activated inward rectifying current is associated with Ca2+ influx. Both the low activation threshold of voltage-dependent Ca2+ channels and the function of I(gl) contribute to the exceptional K+ sensitivity of the glomerulosa cells.

Original languageEnglish
Pages (from-to)429-431
Number of pages3
JournalPflugers Archiv European Journal of Physiology
Volume435
Issue number3
DOIs
Publication statusPublished - 1998

Fingerprint

Rats
Clamping devices
Electric potential
Patch-Clamp Techniques
Chemical activation
Zona Glomerulosa
Fluorometry
Potassium

Keywords

  • Calcium channel
  • Calcium signal
  • Glomerulosa
  • Patch-clamp
  • Potassium

ASJC Scopus subject areas

  • Physiology

Cite this

Electrophysiological study on the high K+ sensitivity of rat glomerulosa cells. / Várnai, P.; Petheö, G.; Makara, Judit K.; Spät, A.

In: Pflugers Archiv European Journal of Physiology, Vol. 435, No. 3, 1998, p. 429-431.

Research output: Contribution to journalArticle

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