Electrophysiological actions of a new antiarrhythmic drug, bisaramil, on isolated heart preparations

Margit Paroczai, Egon Karpati, Raisa Marko, V. Kecskeméti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Electrophysiological effects of bisaramil-a new antiarrhythmic drug under clinical trial-were investigated on isolated heart preparations, at a concentration range of 2.3-23×10-6 m. Bisaramil dose dependently decreased the maximum rate of depolarization (Vmax), action potential amplitude (APA) and overshoot (OS) both in auricle and in papillary muscle of guinea-pig heart. There was no significant and obvious effect on the duration of the action potential and the resting membrane potential was also unchanged. Bisaramil slowed the spontaneous frequency of pacemaker cells in rabbit sinus node preparation due to its inhibitory effect on slow diastolic depolarization (SDD). Bisaramil was able to inhibit slow Ca2+-action potentials induced by isoprenaline on K+-depolarized papillary muscle. Results obtained with transmembrane current measurements revealed that bisaramil inhibited both fast Na+-current and slow Ca2+-current in frog sinoauricular fibres at the same concentration. Bisaramil with a mixed mode of the action seems to be a very promising drug.

Original languageEnglish
Pages (from-to)75-85
Number of pages11
JournalPharmacological Research
Volume25
Issue number1
DOIs
Publication statusPublished - 1992

Fingerprint

Anti-Arrhythmia Agents
Action Potentials
Papillary Muscles
Sinoatrial Node
Isoproterenol
Anura
Membrane Potentials
bisaramil
Isolated Heart Preparation
Guinea Pigs
Clinical Trials
Rabbits
Pharmaceutical Preparations

Keywords

  • 'slow Ca-action potential'
  • pacemaker type action potential
  • transmembrane action potential
  • transmembrane ionic currents

ASJC Scopus subject areas

  • Pharmacology

Cite this

Electrophysiological actions of a new antiarrhythmic drug, bisaramil, on isolated heart preparations. / Paroczai, Margit; Karpati, Egon; Marko, Raisa; Kecskeméti, V.

In: Pharmacological Research, Vol. 25, No. 1, 1992, p. 75-85.

Research output: Contribution to journalArticle

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