Electrophoretic mobility of lymphocytes in neonates with cleft lip/palate and neural tube defect: A pilot study

G. Kosztolanyi, K. Jobst

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study examined the surface charge of lymphocytes in newborns with fusion-type defects. Significant difference was found in the electrophoretic mobility of cells between normal controls (0.89 ± 0.02) and neonates with cleft lip/palate (1.01 ± 0.02; P < 0.01) or neural tube defect (0.99 ± 0.02; P < 0.02). The cell frequency/mobility histograms revealed unimodal distribution for controls, but bimodal distribution for malformed infants of both types. It is suggested that alterations in the genetically determined cell surface charge properties might play an important role in fusion-type defects.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalJournal of Craniofacial Genetics and Developmental Biology
Volume2
Issue number4
Publication statusPublished - Dec 1 1982

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ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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