This study examined the surface charge of lymphocytes in newborns with fusion-type defects. Significant difference was found in the electrophoretic mobility of cells between normal controls (0.89 ± 0.02) and neonates with cleft lip/palate (1.01 ± 0.02; P < 0.01) or neural tube defect (0.99 ± 0.02; P < 0.02). The cell frequency/mobility histograms revealed unimodal distribution for controls, but bimodal distribution for malformed infants of both types. It is suggested that alterations in the genetically determined cell surface charge properties might play an important role in fusion-type defects.
|Number of pages||4|
|Journal||Journal of Craniofacial Genetics and Developmental Biology|
|Publication status||Published - Dec 1 1982|
ASJC Scopus subject areas
- Developmental Biology