Biopsies from 13 cases of leukoderma exfoliativum mucosae oris (white sponge nevus) showed significant changes as compared with the normal ultrastructure. The disease is hereditary, manifesting itself in the disturbed differentiation of epithelial cells mainly of the oral mucosa. The arrangement of the tonofilaments is abnormal and formation of tonofibrils and keratohyaline granules ceases. Odland bodies occur in great number but they do not empty their content into the intercellular spaces. Exfoliation of the epithelial cells diminishes, presumably because of the disturbance of their enzymatic function and the presence of a great number of desmosomes between the cells of the superficial layer. The diminished exfoliation histologically and clinically produces a hyperplasia of the epithelium with an enormous quantity of superficial epithelial cells.
|Number of pages||8|
|Journal||Morphologiai es Igazsagugyi Orvosi Szemle|
|Publication status||Published - Jan 1 1976|
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