Electronic structure and cytotoxic activity of 'half-mustard type' phenothiazines by MM3 and PM3 methods

Teruo Kurihara, Kazumichi Nojima, Hiroshi Sakagami, Noboru Motohashi, J. Molnár

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Among 54 cancer cell lines, colon-cancer cells were the most sensitive to six 'half-mustard type' phenothiazines [7-12], followed by leukemia, melanoma, prostate-, CNS-, breast-, lung-, renal and ovarian cancer cells. The distribution of electrostatic potential (ESP) of 'half-mustard type' phenothiazines [7-12] suggests that the ESP surface urea site is important for the interaction between 'half-mustard type' phenothiazines [7-12] and target cancer cell structures (or DNA base sequence). Actually, the urea site of 'half-mustard type' phenothiazines displayed extensive variability in the energy of lone pair orbital and net atomic charges of N1, O and N3 atoms.

Original languageEnglish
Pages (from-to)3895-3899
Number of pages5
JournalAnticancer Research
Volume19
Issue number5 B
Publication statusPublished - 1999

Fingerprint

Phenothiazines
Mustard Plant
Static Electricity
Urea
Kidney Neoplasms
Ovarian Neoplasms
Colonic Neoplasms
Prostate
Melanoma
Lung Neoplasms
Neoplasms
Leukemia
Breast Neoplasms
Cell Line

Keywords

  • 'Half-mustard type' phenothiazines
  • Cytotoxic activity
  • MM3 method
  • Multiple regression analysis
  • PM3 method

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Electronic structure and cytotoxic activity of 'half-mustard type' phenothiazines by MM3 and PM3 methods. / Kurihara, Teruo; Nojima, Kazumichi; Sakagami, Hiroshi; Motohashi, Noboru; Molnár, J.

In: Anticancer Research, Vol. 19, No. 5 B, 1999, p. 3895-3899.

Research output: Contribution to journalArticle

Kurihara, T, Nojima, K, Sakagami, H, Motohashi, N & Molnár, J 1999, 'Electronic structure and cytotoxic activity of 'half-mustard type' phenothiazines by MM3 and PM3 methods', Anticancer Research, vol. 19, no. 5 B, pp. 3895-3899.
Kurihara, Teruo ; Nojima, Kazumichi ; Sakagami, Hiroshi ; Motohashi, Noboru ; Molnár, J. / Electronic structure and cytotoxic activity of 'half-mustard type' phenothiazines by MM3 and PM3 methods. In: Anticancer Research. 1999 ; Vol. 19, No. 5 B. pp. 3895-3899.
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