Electronic and steric effects of ligands as control elements for rhodium-catalyzed asymmetric hydroformylation. Part 3: Highly active hydroformylation of styrene

Csaba Hegedüs, József Madarász, Ildikó Gergely, Áron Szöllosy, Axel Monsees, Thomas Riermeier, József Bakos

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Abstract

The electronic and steric effects in the rhodium diphosphinite catalyzed asymmetric hydroformylation were investigated. Phosphinite basicity was varied by using 4-CH 3, 4-CF 3, 3,5-(CH 3) 2 and 3,5-(CF 3) 2 substituents on the diphenylphosphine moieties. Two series of ligands based on (S)-BINOL and (S)-H 8-BINOL were synthesized. In the hydroformylation of styrene an increase in l:b ratio, in activity and in enantioselectivity was observed with decreasing phosphinite basicity.

Original languageEnglish
Pages (from-to)2507-2513
Number of pages7
JournalTetrahedron Asymmetry
Volume15
Issue number16
DOIs
Publication statusPublished - Aug 23 2004

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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