The electronic and steric effects in the rhodium diphosphinite catalyzed asymmetric hydroformylation were investigated. Phosphinite basicity was varied by using 4-CH 3, 4-CF 3, 3,5-(CH 3) 2 and 3,5-(CF 3) 2 substituents on the diphenylphosphine moieties. Two series of ligands based on (S)-BINOL and (S)-H 8-BINOL were synthesized. In the hydroformylation of styrene an increase in l:b ratio, in activity and in enantioselectivity was observed with decreasing phosphinite basicity.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry