Lanthanum trichloride was found in earlier experiments to cause complex morphological changes in the liver. These manifested themselves first in a diffuse degenerative regressive damage of liver cells, and later in necrobiotic centrolobular transformation associated with the disappearance of glycogen. Electron microscopically, the early diffuse cell lesion was characterized by nucleo nucleolar alterations which referred to a disturbance of nucleic acid metabolism. While the mitochondria did not show significant alterations, the endoplasmic reticulum displayed changes already at the early stage which progressed gradually and were pointing to a possible inhibition of microsomal enzymes. Electron microscopic studies revealed, in the earliest phase, disorders of intracellular glycogen distribution and later damage of the epithelial cells of biliary ducts not seen under the light microscope.
|Number of pages||15|
|Journal||Acta morphologica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1974|
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