Electron microscopic characteristics of β2-microglobulin amyloid deposits in long-term hemodialysis

M. Bély, Pal Kapp, Tamás Szentjóbi Szabó, Tamás Lakatos, Ágnes Apáthy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The electron microscopic features of β2-microglobulin amyloid, deposited in the synovial membrane, are presented and discussed. The patient, a 69-year-old woman underwent chronic hemodialysis for 3 years. Because of constant pain and destructive arthropathy, endoprosthesis of the hip joints were implanted. Extra- and intracellular filamentous-fibrillar amyloid deposits have been demonstrated in ultrathin sections. The extracellular amyloid deposits showed a loose, filamentous or fibrillar structure at the periphery and a dense central core. The loose, filamentous structure may represent an early stage of fresh, newly deposited β2-microglobulin amyloid, while the condensed and fragmented amyloid filaments may be an advanced "mature" stage of amyloid deposition.

Original languageEnglish
Pages (from-to)483-491
Number of pages9
JournalUltrastructural Pathology
Volume29
Issue number6
DOIs
Publication statusPublished - Nov 2005

Fingerprint

Amyloid Plaques
Amyloid
Renal Dialysis
Deposits
deposits
Electrons
pain
filaments
electrons
membranes
Synovial Membrane
Joint Diseases
Hip Joint
Pain
Membranes

Keywords

  • β2-microglobulin amyloid
  • Early and advanced stage
  • Synovial membrane

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Instrumentation
  • Structural Biology

Cite this

Electron microscopic characteristics of β2-microglobulin amyloid deposits in long-term hemodialysis. / Bély, M.; Kapp, Pal; Szabó, Tamás Szentjóbi; Lakatos, Tamás; Apáthy, Ágnes.

In: Ultrastructural Pathology, Vol. 29, No. 6, 11.2005, p. 483-491.

Research output: Contribution to journalArticle

Bély, M. ; Kapp, Pal ; Szabó, Tamás Szentjóbi ; Lakatos, Tamás ; Apáthy, Ágnes. / Electron microscopic characteristics of β2-microglobulin amyloid deposits in long-term hemodialysis. In: Ultrastructural Pathology. 2005 ; Vol. 29, No. 6. pp. 483-491.
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