Electron microscopic and cytochemical study of the vacuoles of regenerating renal tubular cells

J. Ormos, L. Sztriha, Zs Boti, E. Kuthy

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The structure and acid phosphatase activity of vacuoles observed in regenerating proximal renal tubules of rats were examined ultrastructurally. The sequestration and degradation of organelles were followed in the vacuoles, which obtain the acid phosphatase presumably from the lysosomes, and the limiting membrane of which originates from the endoplasmic reticulum. The vacuoles are regarded as autophagic vacuoles. Their appearance is correlated with the commencing differentiation of the dedifferentiated regenerating cells, which have replaced the entirely necrotic epithelium. Also, cells with partial degradation reveal similar regenerative phenomena.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalBritish journal of experimental pathology
Issue number5
Publication statusPublished - Dec 1 1975


ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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