Electrochromatography in microchips packed with conventional reversed-phase silica particles

Attila Gaspar, Lilia Hernandez, Schetema Stevens, Frank A. Gomez

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This paper shows the applicability of a disposable and inexpensive microfluidic chip for electrochromatographic separations. The chip, recently developed by us for chip-based LC, was fabricated from PDMS incorporating conventional chromatographic RP silica particles (C18) without the use of frits. Three cephalosporin antibiotics were used to demonstrate the applicability of the chip-based chromatographic packing for electrochromatographic determinations. The used sample injection method utilizes hydrodynamic pressure, thereby, reducing the propensity for sample bias during the injection.

Original languageEnglish
Pages (from-to)1638-1642
Number of pages5
JournalELECTROPHORESIS
Volume29
Issue number8
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Chip
  • Electrochromatography
  • Pressure injection
  • Reversed-phase silica particles

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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