Electrochemical Detection of miRNAs

Gergely Lautner, R. Gyurcsányi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. The progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and nanostructures. These enable a rigorous control over the sensing interface, provide enormous signal amplifications and single-base mismatch specificity. Femtomolar or even subfemtomolar detection limits were shown to be feasible by electrochemical assays. Thus electrochemical detection methodologies are of perspective for diagnostic miRNA detection.

Original languageEnglish
Pages (from-to)1224-1235
Number of pages12
JournalElectroanalysis
Volume26
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

MicroRNAs
Assays
Patents and inventions
Amplification
Nanostructures

Keywords

  • Concatamer
  • Electrochemical detection
  • Impedance
  • MiRNA
  • Peptide nucleic acid
  • Resistive pulse sensing
  • Voltammetry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

Cite this

Electrochemical Detection of miRNAs. / Lautner, Gergely; Gyurcsányi, R.

In: Electroanalysis, Vol. 26, No. 6, 2014, p. 1224-1235.

Research output: Contribution to journalArticle

Lautner, Gergely ; Gyurcsányi, R. / Electrochemical Detection of miRNAs. In: Electroanalysis. 2014 ; Vol. 26, No. 6. pp. 1224-1235.
@article{4128828c07784539adaef80fd17d3ba6,
title = "Electrochemical Detection of miRNAs",
abstract = "The recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. The progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and nanostructures. These enable a rigorous control over the sensing interface, provide enormous signal amplifications and single-base mismatch specificity. Femtomolar or even subfemtomolar detection limits were shown to be feasible by electrochemical assays. Thus electrochemical detection methodologies are of perspective for diagnostic miRNA detection.",
keywords = "Concatamer, Electrochemical detection, Impedance, MiRNA, Peptide nucleic acid, Resistive pulse sensing, Voltammetry",
author = "Gergely Lautner and R. Gyurcs{\'a}nyi",
year = "2014",
doi = "10.1002/elan.201400055",
language = "English",
volume = "26",
pages = "1224--1235",
journal = "Electroanalysis",
issn = "1040-0397",
publisher = "Wiley-VCH Verlag",
number = "6",

}

TY - JOUR

T1 - Electrochemical Detection of miRNAs

AU - Lautner, Gergely

AU - Gyurcsányi, R.

PY - 2014

Y1 - 2014

N2 - The recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. The progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and nanostructures. These enable a rigorous control over the sensing interface, provide enormous signal amplifications and single-base mismatch specificity. Femtomolar or even subfemtomolar detection limits were shown to be feasible by electrochemical assays. Thus electrochemical detection methodologies are of perspective for diagnostic miRNA detection.

AB - The recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. The progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and nanostructures. These enable a rigorous control over the sensing interface, provide enormous signal amplifications and single-base mismatch specificity. Femtomolar or even subfemtomolar detection limits were shown to be feasible by electrochemical assays. Thus electrochemical detection methodologies are of perspective for diagnostic miRNA detection.

KW - Concatamer

KW - Electrochemical detection

KW - Impedance

KW - MiRNA

KW - Peptide nucleic acid

KW - Resistive pulse sensing

KW - Voltammetry

UR - http://www.scopus.com/inward/record.url?scp=84902006985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902006985&partnerID=8YFLogxK

U2 - 10.1002/elan.201400055

DO - 10.1002/elan.201400055

M3 - Article

AN - SCOPUS:84902006985

VL - 26

SP - 1224

EP - 1235

JO - Electroanalysis

JF - Electroanalysis

SN - 1040-0397

IS - 6

ER -