Electrical stimulation of the Gasserian ganglion induces structural alterations of calcitonin gene-related peptide-immunoreactive perivascular sensory nerve terminals in the rat cerebral dura mater: a possible model of migraine headache

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Abstract

Calcitonin gene-related peptide (CGRP)- positive sensory nerve fibers in the rat supratentorial cerebral dura mater are equipped with varicosities and club-like nerve terminals, often attached to the walls of blood vessels. Brief electrical stimulation of the Gasserian ganglion results in significant swelling and increased immunohistochemical staining of ipsilateral perivascular club-like terminals, while long-lasting electrical stimulation induces their disintegration or bursting, resulting in irregular, corroded outlines of terminals and en passant beads. Stimulation-induced morphological alterations of perivascular terminals may represent a structural basis of increased CGRP content in jugular blood which follows electrical stimulation of the Gasserian ganglion and accompanies migraine attacks.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalNeuroscience Letters
Volume184
Issue number3
DOIs
Publication statusPublished - Jan 30 1995

Keywords

  • Calcitonin gene-related peptide
  • Dura mater encephali
  • Electrical stimulations
  • Gasserian ganglion
  • Headache
  • Sensory nerve endings

ASJC Scopus subject areas

  • Neuroscience(all)

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