Elastic properties of small intramural coronary arteries of the rat

L. Dézsi, M. Szekeres, G. Nádasy, E. Monos

Research output: Contribution to journalArticle

Abstract

Elastic properties of small intramural coronary arteries of the rat were determined in vitro in order to characterize their mechanical behavior. End branches of the left descendent coronary artery were prepared, cannulated and immersed in a tissue bath. Intraluminal pressure was changed between 0-150 mmHg at a rate of 1 mmHg/sec. Outer diameter of the segments was continuously measured by in vitro microangiometry. Pressure-diameter plots were recorded in spontaneous contraction, in PGF (7.5 × 10-6 M) induced contraction, and in relaxed segments (2.8 × 10-4 M papaverine). At 50 mmHg pressure the segments had an outer radius of 172 ± 17 μm, a wall thickness of 34 ± 12 μm, a spontaneous tone of 10.6 ± 3.4 % and a PGF tone of 17.5 ± 4.0 % of the relaxed diameter. Elastic modulus at 50 mmHg was 6.8 ± 2.6 × 10-6 dyn/cm2, distensibility 9.5 ± 4.0 × 10-6 cm2/dyn. Elastic modulus and distensibility decreased with increasing pressure: the transition between the more distensible and less distensible parts of the pressure radius curve was below the level of in vivo arterial pressures. This study provides novel information on large deformation biomechanics of intramural small coronary arteries. In addition, it shows that these vessels exhibit significant spontaneous myogenic tone and substantial reactivity when stimulated with agonists.

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number3
Publication statusPublished - 1997

Fingerprint

coronary vessels
Rats
Coronary Vessels
Pressure
rats
Dinoprost
Elastic Modulus
modulus of elasticity
Elastic moduli
Papaverine
papaverine
Baths
Biomechanics
Biomechanical Phenomena
Arterial Pressure
agonists
Tissue
In Vitro Techniques

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Elastic properties of small intramural coronary arteries of the rat. / Dézsi, L.; Szekeres, M.; Nádasy, G.; Monos, E.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

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