EFNS guideline on the drug treatment of migraine - Report of an EFNS task force

S. Evers, J. Áfra, A. Frese, P. J. Goadsby, M. Linde, A. May, P. S. Sándor

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel. All available medical reference systems were screened for all kinds of clinical studies on migraine with and without aura and on migraine-like syndromes. The findings in these studies were evaluated according to the recommendations of the EFNS resulting in level A,B, or C recommendations and good practice points. For the acute treatment of migraine attacks, oral non-steroidal anti-inflammatory drugs (NSAIDs) and triptans are recommended. The administration should follow the concept of stratified treatment. Before intake of NSAIDs and triptans, oral metoclopramide or domperidon is recommended. In very severe attacks, intravenous acetylsalicylic acid or subcutaneous sumatriptan are drugs of first choice. A status migrainosus can probably be treated by steroids. For the prophylaxis of migraine, betablockers (propranolol and metoprolol), flunarizine, valproic acid, and topiramate are drugs of first choice. Drugs of second choice for migraine prophylaxis are amitriptyline, naproxen, petasites, and bisoprolol.

Original languageEnglish
Pages (from-to)560-572
Number of pages13
JournalEuropean Journal of Neurology
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Advisory Committees
Migraine Disorders
Guidelines
Pharmaceutical Preparations
Tryptamines
Therapeutics
Petasites
Anti-Inflammatory Agents
Bisoprolol
Flunarizine
Domperidone
Migraine without Aura
Sumatriptan
Migraine with Aura
Naproxen
Metoclopramide
Amitriptyline
Metoprolol
Valproic Acid
Propranolol

Keywords

  • Guideline
  • Headache
  • Migraine
  • Prophylaxis
  • Triptans

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

EFNS guideline on the drug treatment of migraine - Report of an EFNS task force. / Evers, S.; Áfra, J.; Frese, A.; Goadsby, P. J.; Linde, M.; May, A.; Sándor, P. S.

In: European Journal of Neurology, Vol. 13, No. 6, 06.2006, p. 560-572.

Research output: Contribution to journalArticle

Evers, S. ; Áfra, J. ; Frese, A. ; Goadsby, P. J. ; Linde, M. ; May, A. ; Sándor, P. S. / EFNS guideline on the drug treatment of migraine - Report of an EFNS task force. In: European Journal of Neurology. 2006 ; Vol. 13, No. 6. pp. 560-572.
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