Efficient synthesis of pamidronic acid using an ionic liquid additive

A. Grün, Dávid Illés Nagy, Sándor Garadnay, István Greiner, G. Keglevich

Research output: Contribution to journalArticle

10 Citations (Scopus)


An efficient method was developed for the synthesis of pamidronic acid involving the reaction of β-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 °C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.

Original languageEnglish
Pages (from-to)475-478
Number of pages4
JournalLetters in Drug Design and Discovery
Issue number6
Publication statusPublished - Jul 1 2016


  • Additive
  • Best synthesis
  • Intermediate
  • Ionic liquids
  • Pamidronic acid

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine

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