Numerous pharmacologically interesting compounds are available by the synthesis of hybrid natural products. Thus, for instance, the estrone-talaromycin hybrid 2, which is synthesized in a few steps from the estrone derivative 1 by a sequence in which a hetero-Diels-Alder reaction is the key step, exhibits notable cytotoxic activity.
|Number of pages||2|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - Oct 2 1998|
- Antitumor agents
- Spiro compounds
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