Efficient, scalable kinetic resolution of cis-4-benzyloxy-2,3-epoxybutanol

Ferenc Faigl, Angelika Thurner, Melinda Battancs, Ferenc Farkas, László Poppe, Viktória Bódai, Ildikó Kmecz, Béla Simándi

Research output: Contribution to journalArticle

9 Citations (Scopus)


A new enzyme catalysed kinetic resolution of cis-4-benzyloxy-2,3- epoxybutanol has been reported. Efficient, scalable separation of the optically active alcohol from its ester derivative has been solved with liquid-liquid and solid-liquid extraction methods using commercial organic solvents and supercritical carbon dioxide. cis-4-Benzyloxy-2,3-epoxy-1-butanol enantiomers were applied for the enantioselective synthesis of (2S,3S,1′S)- and (2R,3R,1′R)-3-[2′-(dibenzylamino)-1′-hydroxyethyl] -2-phenyloxetane.

Original languageEnglish
Pages (from-to)3841-3847
Number of pages7
JournalTetrahedron Asymmetry
Issue number23
Publication statusPublished - Nov 28 2005

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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