Efficient, racemization-free amidation of protected amino acids

C. Somlai, G. Szokan, L. Balaspiri

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Abstract

N-tert-Butoxycarbonyl derivatives of L-leucine, S-benzyl-L-cysteine and N(τ)-(2,4-dinitrophenyl)-L-histidine were amidated with crystalline ammonium, methylammonium, and ethylammonium salts of 3-hydroxy-1,2,3-benzotriazin-4(3H)-one and N-hydroxy-succinimide to give the corresponding amino acid amides in good yield and with good optical purity.

Original languageEnglish
Pages (from-to)285-287
Number of pages3
JournalSynthesis
Issue number3
Publication statusPublished - Jan 1 1992

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ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Cite this

Somlai, C., Szokan, G., & Balaspiri, L. (1992). Efficient, racemization-free amidation of protected amino acids. Synthesis, (3), 285-287.