Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin

Erzsébet Osz, László Somsák, László Szilágyi, László Kovács, Tibor Docsa, Béla Tóth, Pál Gergely

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Abstract

Reaction of C-(1-bromo-1-deoxy-β-D-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of D- glucopyranosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases.

Original languageEnglish
Pages (from-to)1385-1390
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number10
DOIs
Publication statusPublished - May 17 1999

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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