Efficient heterogeneous racemization of secondary alcohols: Convenient synthesis of 17α-estradiol 3-methyl ether

A. Zsigmond, Anita Kecskeméti, Krisztián Bogár, F. Notheisz, E. Mernyák

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Racemization of optically active secondary alcohols was performed on a heterogeneous Ru/Al2O3 catalyst under mild reaction conditions. The supported ruthenium catalyst is readily available, inexpensive, and capable of being recycled. It successfully racemizes secondary alcohols without any additive or cocatalyst. A convenient synthesis of an expensive steroid alcohol was developed applying the same reaction conditions.

Original languageEnglish
Pages (from-to)520-524
Number of pages5
JournalCatalysis Communications
Volume6
Issue number8
DOIs
Publication statusPublished - Jul 2005

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Methyl Ethers
Estradiol
Ethers
Alcohols
Catalysts
Ruthenium
Steroids

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology

Cite this

Efficient heterogeneous racemization of secondary alcohols : Convenient synthesis of 17α-estradiol 3-methyl ether. / Zsigmond, A.; Kecskeméti, Anita; Bogár, Krisztián; Notheisz, F.; Mernyák, E.

In: Catalysis Communications, Vol. 6, No. 8, 07.2005, p. 520-524.

Research output: Contribution to journalArticle

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