Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L.

Sándor Gonda, Attila Kiss-Szikszai, Zsolt Szucs, Borbála Balla, Gábor Vasas

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In the current study, decomposition of diclofenac, diflunisal, ibuprofen, mefenamic acid and piroxicam was tested using nine identified strains of endophytic and epiphytic fungi (from Ascomycota) adapted to natural products resembling the pharmaceuticals. The strains were isolated from a medicinal plant, Plantago lanceolata leaves. Metabolites were tentatively identified by liquid chromatography - tandem mass spectrometry (LC-MS3). Eighteen of the 45 combinations resulted in significant decrease of the concentration of the NSAIDs in model solutions. The most active strains were Aspergillus nidulans and Bipolaris tetramera, while Epicoccum nigrum and Aspergillus niger showed somewhat less potency. Piroxicam and diclofenac were most resistant to biotransformation, while ibuprofen and mefenamic acid were efficiently metabolized by most strains. Ten metabolites could be tentatively identified, including hydroxy-metabolites of all tested NSAIDs, and a dihydroxy-metabolite of piroxicam. This biotransformation is likely to modify the toxicity and bioaccumulation potential of these pharmaceuticals. The results highlight the applicability of polyphenol-rich dried medicinal plant materials as an excellent source of fungi with high biotransforming potential. The results also suggest more in-depth testing of these fungi for biodegradation processes.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalInternational Biodeterioration and Biodegradation
Volume108
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Biodegradation
  • Biotransformation
  • Endophytes
  • Epiphytic fungi
  • Non-steroid anti-inflammatory drugs
  • Phylloplane fungi

ASJC Scopus subject areas

  • Microbiology
  • Biomaterials
  • Waste Management and Disposal

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