Efficient and selective hydration of nitriles to amides in aqueous systems with Ru(II)-phosphaurotropine catalysts

Evelin Bolyog-Nagy, Antal Udvardy, Ferenc Joó, A. Kathó

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A simple and efficient synthesis of amides by selective hydration of aromatic and aliphatic nitriles is described. The catalysts are prepared in situ from easily available Ru-precursors and ligands using water as the solvent. The most active catalyst, is obtained from [RuCl2(dmso)4] and benzylated 1,3,5-triaza-7-phosphaadamantane. Of the 16 substrates examined, 92-99% conversions of 14 nitriles were achieved in one hour at reflux temperature.

Original languageEnglish
Pages (from-to)3615-3617
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number26
DOIs
Publication statusPublished - Jun 25 2014

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Nitriles
Amides
Hydration
Catalysts
Ligands
Temperature
Water
Substrates
1,3,5-triaza-7-phosphaadamantane

Keywords

  • Amides
  • Nitrile hydration
  • Phosphine
  • Ruthenium

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Efficient and selective hydration of nitriles to amides in aqueous systems with Ru(II)-phosphaurotropine catalysts. / Bolyog-Nagy, Evelin; Udvardy, Antal; Joó, Ferenc; Kathó, A.

In: Tetrahedron Letters, Vol. 55, No. 26, 25.06.2014, p. 3615-3617.

Research output: Contribution to journalArticle

Bolyog-Nagy, Evelin ; Udvardy, Antal ; Joó, Ferenc ; Kathó, A. / Efficient and selective hydration of nitriles to amides in aqueous systems with Ru(II)-phosphaurotropine catalysts. In: Tetrahedron Letters. 2014 ; Vol. 55, No. 26. pp. 3615-3617.
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AU - Kathó, A.

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