Efficacy of single large doses of caspofungin in a neutropenic murine model against the "psilosis" group

Réka Berényi, Renátó Kovács, Marianna Domán, R. Gesztelyi, G. Kardos, B. Juhász, David Perlin, László Majoros

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We compared the in vivo efficacy of single large dose of caspofungin to that of daily smaller caspofungin doses (with same cumulative doses) against C. albicans (echinocandin susceptible and resistant isolates) and the "psilosis" group in a neutropenic murine model. Seven treatment groups were formed for C. orthopsilosis, C. metapsilosis and C. albicans (no treatment, 1, 2 and 3 mg/kg caspofungin daily for five days; single 5, 10 and 15 mg/kg caspofungin doses). For C. parapsilosis there were five treatment groups (no treatment, 3 and 4 mg/kg caspofungin daily for five days; single 15 and 20 mg/kg caspofungin). Tissue burdens of C. orthopsilosis and C. parapsilosis were significantly decreased by daily 3 mg/kg and 10 or 15 mg/kg single caspofungin doses (P

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalNew Microbiologica
Volume37
Issue number3
Publication statusPublished - 2014

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caspofungin

Keywords

  • Candida albicans
  • Candida parapsilosis
  • Echinocandin-resistant
  • Echinocandins
  • Fungal tissue burden
  • Intermittent dosing regimen

ASJC Scopus subject areas

  • Microbiology (medical)

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Efficacy of single large doses of caspofungin in a neutropenic murine model against the "psilosis" group. / Berényi, Réka; Kovács, Renátó; Domán, Marianna; Gesztelyi, R.; Kardos, G.; Juhász, B.; Perlin, David; Majoros, László.

In: New Microbiologica, Vol. 37, No. 3, 2014, p. 355-362.

Research output: Contribution to journalArticle

Berényi, Réka ; Kovács, Renátó ; Domán, Marianna ; Gesztelyi, R. ; Kardos, G. ; Juhász, B. ; Perlin, David ; Majoros, László. / Efficacy of single large doses of caspofungin in a neutropenic murine model against the "psilosis" group. In: New Microbiologica. 2014 ; Vol. 37, No. 3. pp. 355-362.
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