Efficacy of single large doses of caspofungin in a neutropenic murine model against the "psilosis" group

Réka Berényi, Renátó Kovács, Marianna Domán, Rudolf Gesztelyi, Gábor Kardos, Béla Juhász, David Perlin, László Majoros

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3 Citations (Scopus)


We compared the in vivo efficacy of single large dose of caspofungin to that of daily smaller caspofungin doses (with same cumulative doses) against C. albicans (echinocandin susceptible and resistant isolates) and the "psilosis" group in a neutropenic murine model. Seven treatment groups were formed for C. orthopsilosis, C. metapsilosis and C. albicans (no treatment, 1, 2 and 3 mg/kg caspofungin daily for five days; single 5, 10 and 15 mg/kg caspofungin doses). For C. parapsilosis there were five treatment groups (no treatment, 3 and 4 mg/kg caspofungin daily for five days; single 15 and 20 mg/kg caspofungin). Tissue burdens of C. orthopsilosis and C. parapsilosis were significantly decreased by daily 3 mg/kg and 10 or 15 mg/kg single caspofungin doses (P<0.05-0.01) and daily 4 mg/kg and by single 15 and 20 mg/kg caspofungin doses (P<0.05-0.01), respectively. Against C. metapsilosis all treatment arms except the daily 1 mg/kg were effective (P<0.05-<0.001). Against C. albicans all treatment doses were effective. Neither daily 16 mg/kg nor single 80 mg/kg were effective against the resistant C. albicans strain. Higher doses and less frequent administration of caspofungin were comparable or sometimes superior to the lower, daily-dose regimen against the "psilosis" group supporting further studies with this therapeutic strategy.

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalNew Microbiologica
Issue number3
Publication statusPublished - Jul 2014


  • Candida albicans
  • Candida parapsilosis
  • Echinocandin-resistant
  • Echinocandins
  • Fungal tissue burden
  • Intermittent dosing regimen

ASJC Scopus subject areas

  • Microbiology (medical)

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