Prosztanoidok hatásossága kritikus vé gtagischaemiában

Translated title of the contribution: Efficacy of prostanoids in patients with critical leg ischemia

Valentin Brodszky, Katalin Farkas, Zoltán Járai, Anna Landi, Zsolt Pécsvárady, Petra Baji, Orsolya Balogh, László Gulácsi, Márta Péntek

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Prostanoids (alprostadil and iloprost) are used for the treatment of patients with critical limb ischemia in whom revascularization procedure is inadequate or proved to be unsuccessful. According to a Cochrane analysis (CD006544) prostanoids differ in their effects on rest-pain relief and ulcer healing. Objectives: To study the efficacy and safety of prostanoids for critical limb ischemia. Methods: Systematic literature search and meta-analysis (mixed treatment comparison) was performed. Results: Seven randomized controlled trials including 964 patients were analyzed. Compared to placebo, both alprostadil (OR: 3.2 95% CI: 1.7-5.5 and OR: 1.8 95% CI: 0.6-4.3) and iloprost (OR: 2.7 95% CI: 1.7-4.2 and OR: 2.5 95% CI: 1.0-5.4) were more efficacious with regard to rest-pain relief and ulcer healing and the difference between the two prostanoids was not significant (OR: 1.2 95% CI: 0.7-1.9 and OR: 0.74 95% CI: 0.3-1.5). Adverse events occurred significantly more often with both drugs compared to placebo, however, they were less frequent with alprostadil than with iloprost (OR 0.2 95% CI: 0.1-0.3). Conclusions: Prostanoids have favorable effect on rest-pain relief and ulcer healing in critical limb ischemia, without statistically significant difference between the two available drugs. The Cochrane study (CD006544) reported mistaken results due to defaults in the analysis.

Original languageHungarian
Pages (from-to)2047-2055
Number of pages9
JournalOrvosi hetilap
Volume152
Issue number51
DOIs
Publication statusPublished - Dec 1 2011

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Brodszky, V., Farkas, K., Járai, Z., Landi, A., Pécsvárady, Z., Baji, P., Balogh, O., Gulácsi, L., & Péntek, M. (2011). Prosztanoidok hatásossága kritikus vé gtagischaemiában. Orvosi hetilap, 152(51), 2047-2055. https://doi.org/10.1556/OH.2011.29277