Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study

Syed M. Nurulain, Shreesh Ojha, Kornelia Tekes, Mohammad Shafiullah, Huba Kalasz, Abdu Adem

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There are a great number of reports with assertions that oxidative stress is produced by organophosphorus compound (OPC) poisoning and is a cofactor of mortality and morbidity in OPC toxicity. In addition, antioxidants have been suggested as adjuncts to standard therapy. However, there is no substantial evidence for the benefit of the use of antioxidants in survival after acute intoxication of OPCs. The present study was conducted to assess the effectiveness of three non-enzymatic antioxidants (NEAOs), N-acetylcysteine (NAC), glutathione (GSH), and ascorbic acid (AA), in acute intoxication of adult male Wister rats with paraoxon. The efficacy of the antioxidants was estimated as both a pretreatment and a concurrent application along with the standard oxime, pralidoxime (2-PAM). Relative risk of death after 48 hours of application was estimated by Cox regression analysis. The results revealed no benefit of either tested NEAO to the improvement in survival of experimental rats. The application of these antioxidants was found to be deleterious when administered along with pralidoxime compared to the treatment with pralidoxime alone. It has been concluded that the tested non-enzymatic antioxidants are not useful in acute toxicity for improving survival rates. However, the individual toxic dynamics of diversified OPCs should not be overlooked and further studies with different OPCs are suggested.

Original languageEnglish
Article number329306
JournalOxidative Medicine and Cellular Longevity
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Paraoxon
Acetylcysteine
Ascorbic Acid
Glutathione
Toxicity
Wistar Rats
Rats
Antioxidants
Organophosphorus Compounds
Organophosphate Poisoning
Oxidative stress
Oximes
Poisons
Regression analysis
Oxidative Stress
Survival Rate
Regression Analysis
Morbidity
Mortality
pralidoxime

ASJC Scopus subject areas

  • Cell Biology
  • Ageing
  • Biochemistry

Cite this

Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats : Survival Study. / Nurulain, Syed M.; Ojha, Shreesh; Tekes, Kornelia; Shafiullah, Mohammad; Kalasz, Huba; Adem, Abdu.

In: Oxidative Medicine and Cellular Longevity, Vol. 2015, 329306, 2015.

Research output: Contribution to journalArticle

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