Efficacy of ivermectin and moxidectin injection against larvae of wohlfahrtia magnifica (Diptera: Sarcophagidae) in sheep

R. Farkas, Martin J R Hall, Mihály Daniel, Lászlo Börzsönyi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The therapeutic efficacies of ivermectin (Ivomec injection, Merck Sharp & Dohme B.V.) and moxidectin (Cydectin 1% injection, American Cyanamid Company) were evaluated in sheep naturally infested with larvae of Wohlfahrtia magnified. Sheep were randomly allocated to one of the 2 groups, each consisting of 19 animals. Sheep in one group received ivermectin and those in the other, moxidectin by subcutaneous injection at a dose of 0.2 mg/kg body weight. Evaluation was performed at 19, 24, 28, 39, 43, 48, 52, 63, 67, 72, 87, 96, 120, 144 and 168 h after treatment. At 144 and 168 h post-treatment, late third-instar larvae were collected from wounds of four sheep in both groups and from untreated, infested sheep. These larvae were reared in the laboratory to assess adult emergence. Neither ivermectin nor moxidectin was effective as a rapid acting treatment or as a long-term, or even short-term, prophylactic. Despite the treatment, 30-40% of sheep had live larvae at every evaluation. Although larvae disappeared from the wounds of some sheep in both groups after the treatment, the wounds in these animals failed to recover and were reinfested by larvae of W. magnified. On day 7 post-treatment the trial had to be finished because the majority of treated sheep were severely infested by Wohlfahrtia maggots. The average number of infested sheep in the two groups and the number of adults that were produced from larvae collected from treated sheep indicate that ivermectin and moxidectin did not differ significantly in efficacy.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalParasitology Research
Volume82
Issue number1
DOIs
Publication statusPublished - Jan 1996

Fingerprint

Wohlfahrtia magnifica
Sarcophagidae
Ivermectin
moxidectin
ivermectin
Diptera
Larva
Sheep
injection
sheep
Injections
larvae
Wohlfahrtia
animal injuries
Therapeutics
Wounds and Injuries
milbemycin
wound treatment
subcutaneous injection
Subcutaneous Injections

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Efficacy of ivermectin and moxidectin injection against larvae of wohlfahrtia magnifica (Diptera : Sarcophagidae) in sheep. / Farkas, R.; Hall, Martin J R; Daniel, Mihály; Börzsönyi, Lászlo.

In: Parasitology Research, Vol. 82, No. 1, 01.1996, p. 82-86.

Research output: Contribution to journalArticle

Farkas, R. ; Hall, Martin J R ; Daniel, Mihály ; Börzsönyi, Lászlo. / Efficacy of ivermectin and moxidectin injection against larvae of wohlfahrtia magnifica (Diptera : Sarcophagidae) in sheep. In: Parasitology Research. 1996 ; Vol. 82, No. 1. pp. 82-86.
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