Four field trials were carried out on large-scale dairy farms in Hungary to assess the efficacy of different therapeutic protocols in terms of reproduction performance for the treatment of puerperal metritis (PM) and clinical endometritis (EM). For the PM therapy (Table 1), oxitetracycline (OTC), amoxicillin (AMO) and gentamycin (GEN) products were used in intrauterine (IU) route, which were supported by parenteral (im.) application of the same antibiotics for the cows developing systemic, general signs of the disease. A high dose (3 g/day) of OTC treatment proved to be more efficacious than the two other antimicrobials in terms of lower frequency of EM (33% vs. 58% in both), as well as lower incidence of Arcanobacterium pyogenes (A. pyogenes) as primary uterine pathogen (24% vs. 50%). Statistically significant difference were also found in higher fertility rate (69% vs. 42% and 44% respectively) and shorter service period (95±25, 113±29,116±27 days, respectively). EM treatment was studied in three different trials, where the following compounds were used: cephapyrin (in 2 trials), penicillin-neomycin (in 1 trial) and inorganic iodine (in 1 trial) used IU, while PGF2α and tylosine applied im. Cephapyrin and tylosin were tested concomitantly with PGF2α as well. Concerning EM significantly lower proportion of animals became pregnant regardless of treatment among A. pyogenes infected cows than those of A. pyogenes free ones (50% vs. 76%). Marked improvement in fertility rate, as compared to untreated control group was observed mostly after cephapyrin IU treatment(65% vs. 52% and 67% vs. 49% in two trials), but also was demonstrated after tylosin im. treatment (68% vs. 55%) and PGF 2α (65% vs. 52%; 63% vs. 49% and 67% vs. 55% in three trials) treatment. These differences were statistically significant only, when the data of A. pyogenes carrier cows were analyzed separately. Penicillin-neomycin combination did not show any effect in terms of reproduction performance (53%vs. 52%). Despite its still relatively common use in practice, inorganic iodine had also no effect at all (52% vs. 52%). No further improvement was demonstrated in the cases of concomitant treatment with PGF2α and either cephapyrin or tylosine. These data proved that in postpartum dairy cows certain antimicrobials represent real value in the therapy of bacterial complications of uterine involution, especially in PM, and in cows with A. pyogenes infected uterus. When ingredient is selected, the characteristics of the postpartum uterus, and the microbial feature of the complication should be considered. For the confirmation of real efficacy, however, clinical and microbial findings should be compared with data on re-conception.
|Translated title of the contribution||Efficacy of different antimicrobial therapeutic protocols for the treatment of puerperal metritis and endometritis in dairy cows|
|Number of pages||10|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - Dec 1 2007|
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