Effects on sperms’ quality of selegiline in aged rats

H. Kalász, Julianna Thuróczy, Gellért Karvaly, L. Balogh, István Gyertyán, Edit Tóth Molnár, Ernest Adeghate, K. Tekes

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. Objective: Scouting special and beneficial side effects of selegiline treatment. Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment. Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased. Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

Original languageEnglish
Pages (from-to)138-145
Number of pages8
JournalOpen Medicinal Chemistry Journal
Volume11
DOIs
Publication statusPublished - Nov 1 2017

Fingerprint

Selegiline
Spermatozoa
Sperm Motility
Subcutaneous Injections
Testis
Wistar Rats
Therapeutics

Keywords

  • Aged-rats
  • Cortisol
  • Dopamine
  • Selegiline
  • Semen
  • Sperm
  • Testis
  • Testosterone

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Effects on sperms’ quality of selegiline in aged rats. / Kalász, H.; Thuróczy, Julianna; Karvaly, Gellért; Balogh, L.; Gyertyán, István; Molnár, Edit Tóth; Adeghate, Ernest; Tekes, K.

In: Open Medicinal Chemistry Journal, Vol. 11, 01.11.2017, p. 138-145.

Research output: Contribution to journalArticle

Kalász, H. ; Thuróczy, Julianna ; Karvaly, Gellért ; Balogh, L. ; Gyertyán, István ; Molnár, Edit Tóth ; Adeghate, Ernest ; Tekes, K. / Effects on sperms’ quality of selegiline in aged rats. In: Open Medicinal Chemistry Journal. 2017 ; Vol. 11. pp. 138-145.
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