Effects on sperms’ quality of selegiline in aged rats

Huba Kalász, Julianna Thuróczy, Gellért Karvaly, Lajos Balogh, István Gyertyán, Edit Tóth Molnár, Ernest Adeghate, Kornélia Tekes

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. Objective: Scouting special and beneficial side effects of selegiline treatment. Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment. Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased. Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

Original languageEnglish
Pages (from-to)138-145
Number of pages8
JournalOpen Medicinal Chemistry Journal
Volume11
DOIs
Publication statusPublished - Nov 1 2017

Keywords

  • Aged-rats
  • Cortisol
  • Dopamine
  • Selegiline
  • Semen
  • Sperm
  • Testis
  • Testosterone

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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