Effects on renal hemodynamics of intra-arterial infusions of angiotensins I and II

L. Rosivall, L. G. Navar

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Experiments were conducted in anesthetized dogs to evaluate the differences between the effects of intrarenal conversion of angiotensin I (ANG I) to angiotensin II (ANG II) and those of circulating ANG II on renal blood flow (RBF), glomerular filtration rate (GFR), peritubular capillary pressure (PCP), proximal tubular free-flow pressure (PTP), and stop-flow pressure (SFP). Equiconstrictor doses of ANG I and ANG II were infused into the renal arteries of dogs kept on normal and high sodium diets. In clearance experiments, RBF decreased by 23% (low dose) and 33% (high dose) during the infusion of either ANG I or ANG II; GFR was significantly reduced only during the ANG I infusion. In micropuncture experiments, in which the GFR responses were similar, there were significant reductions in PTP (23 ± 3%) and PCP (33 ± 3%) during the intrarenal ANG I infusion; SFP was not altered significantly. Afferent and efferent arteriolar resistances increased significantly during ANG I infusion as well as during infusion of ANG II. These results indicate that during intra-arterial infusion of ANG I, the conversion to ANG II within the kidney occurs early enough to decrease glomerular filtration rate through an apparent increase in preglomerular resistance.

Original languageEnglish
Pages (from-to)F181-F187
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume14
Issue number2
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Physiology

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