Effects of vinyl chloride exposure alone and in combination with trypan blue - applied systematically during all thirds of pregnancy on the fetuses of CFY rats

Gy Ungváry, Aranka Hudák, E. Tátrai, M. Lörincz, G. Folly

Research output: Contribution to journalArticle

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Abstract

Vinyl chloride (VC) has been shown to be present in the fetal and maternal blood as well as in the amniotic fluid after the exposition of pregnant CFY rats mg/m3 (∼200 7000 or 12 000 ppm) for 2.5 h on the 18th day of pregnancy, indicating the permeability of the placenta to the agent. Teratological investigation of the offspring of pregnant rats exposed continuously to VC at an atmospheric concentration of 4000 mg/m3 air (1500 ppm) during the first, second or last third of pregnancy has shown that VC has no teratological effect in the rat and has no embryotoxic effects either, when applied during the second or last third of pregnancy in the above concentration. Exposition to VC during the first third of pregnancy resulted in an increased fetal mortality and in the manifestation of embryotoxic effects. Fetal losses and induction of central nervous system malformation due to trypan blue administration were not potentiated by a combined exposure of pregnant rats to VC and the dye.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalToxicology
Volume11
Issue numberC
DOIs
Publication statusPublished - 1978

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Vinyl Chloride
Trypan Blue
Rats
Fetus
Pregnancy
Nervous System Malformations
Fetal Mortality
Neurology
Amniotic Fluid
Fetal Blood
Placenta
Permeability
Blood
Coloring Agents
Central Nervous System
Air
Mothers
Fluids

ASJC Scopus subject areas

  • Toxicology

Cite this

Effects of vinyl chloride exposure alone and in combination with trypan blue - applied systematically during all thirds of pregnancy on the fetuses of CFY rats. / Ungváry, Gy; Hudák, Aranka; Tátrai, E.; Lörincz, M.; Folly, G.

In: Toxicology, Vol. 11, No. C, 1978, p. 45-54.

Research output: Contribution to journalArticle

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